Genetics of macular drusen formation in rhesus macaques - Genetik makulärer Drusen beim Rhesusaffen

这个项目的目的是在一个灵长类动物模型，即卡约圣地亚哥恒河猴中，识别黄斑玻璃体形成的遗传成分(S)，这是年龄相关性黄斑变性的最初临床表现。重点将放在与人类染色体6q14-15同源的区域的候选基因上，这些基因在之前的遗传关联研究中被发现有牵连。这些基因将被筛选出与玻璃体形成相关的突变，并将在受影响和未受影响的组织中研究它们的表达。

This project aims at identifying genetic component(s) of macular drusen formation, the initial clinical manifestation of age-related macular degeneration, in a primate model, namely the Cayo Santiago rhesus macaque. The focus will be on candidate genes in the region orthologous to human chromosome 6q14-15, found to be implicated in preceding genetic association studies. These genes will be screened for mutations associated with drusen formation, and their expression will be studied in both affected and non-affected tissues.