The study on the regulatory mechanism of NADPH oxidase (Nox) 5alpha and 4 redox signaling involved in cancer development

NADPH氧化酶(Nox)5α和4氧化还原信号参与癌症发生的调控机制研究

• 批准号: 16K08628
• 负责人: Kamata Tohru
• 金额: $ 3.08万
• 依托单位: University of Miyazaki
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08628/
• 关键词: NADDPH oxidase(Nox); 分子腫瘍学; 活性酸素; HLV-1; すい臓がん; NADPH oxidase (Nox); HTLV-1; NADPH oxidase(Nox); Nox

项目成果

Identification and characterization of NOS31, a novel selective Nox1 inhibitor

新型选择性 Nox1 抑制剂 NOS31 的鉴定和表征

• 发表时间: 2018

Superoxide-generating Nox5alpa contributes to malignancy of human T-cell leukemia virus type 1-transformed cells through redox regulation

产生超氧化物的 Nox5alpa 通过氧化还原调节导致人类 T 细胞白血病病毒 1 型转化细胞的恶性肿瘤

• 发表时间: 2016
• 作者: Tomonari Shigemura;Masaaki Shiohara;Masayoshi Kato;Kazuko Kaneda;Kazuhiro Morishita;Hiroo Hasegawa;Masahiro Fujii;Agnes Gorlach;Kenichi Koike;Tohru Kamata
• 通讯作者: Tohru Kamata

The ROS-generating oxidase Nox1 is required for epithelial restitution following colitis.

• DOI: 10.1538/expanim.15-0127
• 发表时间: 2016-07-29
• 期刊: Experimental animals
• 影响因子: 2.4
• 作者: Kato M;Marumo M;Nakayama J;Matsumoto M;Yabe-Nishimura C;Kamata T
• 通讯作者: Kamata T

Identification and Characterization of a Novel NADPH Oxidase 1 (Nox1) Inhibitor That Suppresses Proliferation of Colon and Stomach Cancer Cells

抑制结肠癌细胞和胃癌细胞增殖的新型 NADPH 氧化酶 1 (Nox1) 抑制剂的鉴定和表征

• DOI: 10.1248/bpb.b17-00804
• 发表时间: 2018
• 期刊: Biological and Pharmaceutical Bulletin
• 影响因子: 2
• 作者: Yamamoto T;Nakano H;Shiomi K;Wanibuchi K;Masui H;Takahashi T;Urano Y;and Kamata T
• 通讯作者: and Kamata T