Investigation into unraveling the mechanism of drug delivery system to the inner ear

揭示内耳药物输送系统机制的研究

• 批准号: 16K11180
• 负责人: Kita Tomoko
• 金额: $ 3万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K11180/
• 关键词: 内耳蝸牛; 薬物送達; 血液内耳関門; 内耳; ドラッグデリバリー; ナノキャリア

项目成果

Calpain inhibitor alleviates permanent hearing loss induced by intense noise by preventing disruption of gap junction‐mediated intercellular communication in the cochlear spiral ligament

• DOI: 10.1016/j.ejphar.2017.03.058
• 发表时间: 2017-05
• 期刊: European Journal of Pharmacology
• 影响因子: 5
• 作者: Taro Yamaguchi;M. Yoneyama;K. Ogita

Quantitative Analysis of Aquaporin Expression Levels during the Development and Maturation of the Inner Ear

• DOI: 10.1007/s10162-016-0607-3
• 发表时间: 2017-04-01
• 期刊: JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
• 影响因子: 2.4
• 作者: Miyoshi, Takushi;Yamaguchi, Taro;Yamamoto, Norio
• 通讯作者: Yamamoto, Norio

The Use of a Microfluidic Device to Encapsulate a Poorly Water-Soluble Drug CoQ10 in Lipid Nanoparticles and an Attempt to Regulate Intracellular Trafficking to Reach Mitochondria

• DOI: 10.1016/j.xphs.2019.04.001
• 发表时间: 2019-08-01
• 期刊: JOURNAL OF PHARMACEUTICAL SCIENCES
• 影响因子: 3.8
• 作者: Hibino, Mitsue;Yamada, Yuma;Harashima, Hideyoshi
• 通讯作者: Harashima, Hideyoshi

Validation of the use of an artificial mitochondrial reporter DNA vector containing a Cytomegalovirus promoter for mitochondrial transgene expression.

验证使用含有巨细胞病毒启动子的人工线粒体报告 DNA 载体进行线粒体转基因表达。

• DOI: 10.1016/j.biomaterials.2017.05.016
• 发表时间: 2017
• 期刊: Biomaterials.
• 作者: Yamada Y;Ishikawa T;Harashima H.
• 通讯作者: Harashima H.

FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia

• DOI: 10.1073/pnas.1719861115
• 发表时间: 2018-08-14
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Honda, Akira;Kita, Tomoko;Ladher, Raj K.
• 通讯作者: Ladher, Raj K.