Elucidation of pathological mechanism caused by defects in the repair of TOPII-induced DNA double-strand breaks

阐明TOPII诱导的DNA双链断裂修复缺陷引起的病理机制

• 批准号: 16H02953
• 负责人: SASANUMA Hiroyuki
• 金额: $ 11.56万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H02953/
• 关键词: ゲノム; ゲノム編集; 相同組換え; DNA損傷修復; DNA二重鎖切断; ステロイドホルモン; トポイソメラーゼ2; トポイソメラーゼ２; トポイソメラーゼII型; エトポシド; オーキシンデグロン

项目成果

The essential roleof Mre11-Rad50-Nbs1 complex in the removal of abortive top2-DNA complex

Mre11-Rad50-Nbs1 复合物在去除失效的 top2-DNA 复合物中的重要作用

• 发表时间: 2017
• 作者: Hane Y;Kimura S;Yokoyama Y;Miyairi Y;Ushikubo T;Ishimura T;Ogawa N;Aono T;Nishida K;Hiroyuki Sasanuma
• 通讯作者: Hiroyuki Sasanuma

The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C).

• DOI: 10.18632/oncotarget.16508
• 发表时间: 2017-05-16
• 期刊: Oncotarget
• 作者: Tsuda M;Terada K;Ooka M;Kobayashi K;Sasanuma H;Fujisawa R;Tsurimoto T;Yamamoto J;Iwai S;Kadoda K;Akagawa R;Huang SN;Pommier Y;Sale JE;Takeda S;Hirota K
• 通讯作者: Hirota K

Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC-deficient cells.

• DOI: 10.18632/oncotarget.10928
• 发表时间: 2016-09-13
• 期刊: Oncotarget
• 作者: Hashimoto K;Sharma V;Sasanuma H;Tian X;Takata M;Takeda S;Swenberg JA;Nakamura J
• 通讯作者: Nakamura J

TDP1 is Critical for the Repair of DNA Breaks Induced by Sapacitabine, a Nucleoside also Targeting ATM- and BRCA-Deficient Tumors.

• DOI: 10.1158/1535-7163.mct-17-0110
• 发表时间: 2017-11
• 期刊: Molecular cancer therapeutics
• 影响因子: 5.7
• 作者: Al Abo M;Sasanuma H;Liu X;Rajapakse VN;Huang SY;Kiselev E;Takeda S;Plunkett W;Pommier Y
• 通讯作者: Pommier Y

BRCA1-Mre11 ensures genome integrity by eliminating estrogen-induced pathological Topoisomerase II-DNA complexes

BRCA1-Mre11 通过消除雌激素诱导的病理性拓扑异构酶 II-DNA 复合物来确保基因组完整性

• 发表时间: 2019
• 作者: Song;P.;S. Tanabe and S. Ban;Hiroyuki Sasanuma
• 通讯作者: Hiroyuki Sasanuma