Elucidation of regulated mechanism in controlling purine metabolism through PI3K/mTOR pathway in small cell lung cancer

阐明小细胞肺癌中PI3K/mTOR通路控制嘌呤代谢的调节机制

• 批准号: 17K07189
• 负责人: Makinoshima Hideki
• 金额: $ 3.16万
• 依托单位: National Cancer Center Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K07189/
• 关键词: 肺小細胞がん; PI3K/mTOT経路; プリンヌクレオチド; 核酸代謝; PI3K/mTOR経路; プリン塩基; 癌

项目成果

Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry

• DOI: 10.3791/59551
• 发表时间: 2019-06-01
• 期刊: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
• 影响因子: 1.2
• 作者: Maruyama, Ami;Kami, Kenjiro;Makinoshima, Hideki
• 通讯作者: Makinoshima, Hideki

Metabolic Characterization of Antifolate Responsiveness and Non-responsiveness in Malignant Pleural Mesothelioma Cells.

• DOI: 10.3389/fphar.2018.01129
• 发表时间: 2018
• 期刊: Frontiers in pharmacology
• 影响因子: 5.6
• 作者: Sato Y;Matsuda S;Maruyama A;Nakayama J;Miyashita T;Udagawa H;Umemura S;Yanagihara K;Ochiai A;Tomita M;Soga T;Tsuchihara K;Makinoshima H
• 通讯作者: Makinoshima H

Genetic profiling-based prognostic prediction of patients with advanced small-cell lung cancer in large scale analysis

• DOI: 10.1016/j.lungcan.2018.11.014
• 发表时间: 2018-12-01
• 期刊: LUNG CANCER
• 影响因子: 5.3
• 作者: Udagawa, Hibiki;Umemura, Shigeki;Goto, Koichi
• 通讯作者: Goto, Koichi

がん細胞における核酸サルベージ経路の重要性

核酸挽救途径在癌细胞中的重要性

• 发表时间: 2019
• 作者: Kazuma Ishikawa;Yutaka Kawano;Yohei Arihara;Tomohiro Kubo;Kohichi Takada;Kazuyuki Murase;Koji Miyanishi;Masayoshi Kobune;Junji Kato;Makinoshima H et al.;牧野嶋 秀樹
• 通讯作者: 牧野嶋 秀樹

Metabolic Determinants of Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitor in Small-Cell Lung Carcinoma

• DOI: 10.1158/0008-5472.can-17-2109
• 发表时间: 2018-05-01
• 期刊: CANCER RESEARCH
• 影响因子: 11.2
• 作者: Makinoshima, Hideki;Umemura, Shigeki;Tsuchihara, Katsuya
• 通讯作者: Tsuchihara, Katsuya