Non-equilibrium phase transitions in multicellular system

多细胞系统中的非平衡相变

• 批准号: 17J07573
• 负责人: 楼 玉テイ
• 金额: $ 1.09万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for JSPS Fellows
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-26 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17J07573/
• 关键词: Aging; Multicellular aging; Nonequilibrium; Dynamical scaling; Cell cycle arrest; Phase transition

This year I have achieved progress in the theoretical demonstration on the systematic aging of multicellular systems and related this physical aging to a sort of non-equilibrium phase transition. Also, based on the theory, I have designed a new set of experiment for further investigation on the mechanism of aging of multicellular system. The simple model is a stochastic cellular automaton with the state of a cell flipping among division, death, and cell cycle arrest based on a set of rules of fundamental cell biology. Through analysis, it is found that the mechanism underlying regards the existence of multiple phases while the healthiest homeostasis stands on the boundary between the tumorigenic phase and the degenerative phase and undergoes a kind of absorbing phase transition as aging. The results of model analysis has been submitted to the Journal of Royal Society Open Science and the results of experiments have been presented at the 10th European Conference of Mathematical and Theoretical Biology.

今年，我在多细胞系统系统老化的理论论证方面取得了进展，并将这种物理老化与一种非平衡相变联系起来。并在此理论的基础上，设计了一套新的实验，为进一步研究多细胞系统的老化机制奠定了基础。这个简单的模型是一个随机的细胞自动机，根据一套基本的细胞生物学规则，细胞的状态在分裂、死亡和细胞周期停滞之间切换。通过分析发现，其背后的机制是多个阶段的存在，而最健康的动态平衡处于成瘤期和退化期的交界处，随着年龄的增长经历了一种吸收相变。模型分析的结果已提交给皇家学会开放科学杂志，实验结果已在第10届欧洲数学与理论生物学会议上公布。