Non-equilibrium phase transitions in multicellular system

今年，我在多细胞系统的系统老化的理论论证方面取得了进展，并将这种物理老化与一种非平衡相变联系起来。在此基础上，设计了一套新的实验，以进一步研究多细胞系统的衰老机制。简单的模型是一个随机的细胞自动机与分裂，死亡和细胞周期停滞之间翻转的细胞状态的基础上的一套规则的细胞生物学。通过分析发现，其机制认为存在多个阶段，而最健康的稳态处于致瘤阶段和退化阶段之间的边界，并随着衰老而经历一种吸收相变。 模型分析结果已提交给皇家学会开放科学杂志，实验结果已在第10届欧洲数学和理论生物学会议上发表。

This year I have achieved progress in the theoretical demonstration on the systematic aging of multicellular systems and related this physical aging to a sort of non-equilibrium phase transition. Also, based on the theory, I have designed a new set of experiment for further investigation on the mechanism of aging of multicellular system. The simple model is a stochastic cellular automaton with the state of a cell flipping among division, death, and cell cycle arrest based on a set of rules of fundamental cell biology. Through analysis, it is found that the mechanism underlying regards the existence of multiple phases while the healthiest homeostasis stands on the boundary between the tumorigenic phase and the degenerative phase and undergoes a kind of absorbing phase transition as aging. The results of model analysis has been submitted to the Journal of Royal Society Open Science and the results of experiments have been presented at the 10th European Conference of Mathematical and Theoretical Biology.