PEPT1 ENHANCED BACTERIAL PEPTIDE TRANSPORT INTO LNFLAMED COLONIC EPITHELIUM AND INDUCES NEUTROPHIL RECRUITMENT

PEPT1 增强细菌肽转运至发炎的结肠上皮并诱导中性粒细胞募集

• 批准号: 17K09398
• 负责人: WATANABE CHIKAKO
• 金额: $ 2.83万
• 依托单位: National Defense Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K09398/
• 关键词: ペプチド; 輸送体; 腸; 粘膜上皮; ペプチド輸送体; 腸管免疫; 内科

项目成果

UPREGULATION OF PEPT1 AND BACTERIAL DERIVED PEPTIDES TRANSPORT MAY ENHANCE THE NEUTROPHIL TRAFFICKING IN LPSINDUCED COLONIC INFLAMMATION

PPT1 和细菌衍生肽转运的上调可能会增强 LPS 引起的结肠炎症中的中性粒细胞运输

• 发表时间: 2017
• 作者: Chikako Watanabe;Soihiro Miura;Ryota Hokari
• 通讯作者: Ryota Hokari

PEPT1 ENHANCED BACTERIAL PEPTIDE TRANSPORT INTO LPS-TREATED COLONIC EPITHELIUM AND INDUCES NEUTROPHIL RECRUITMENT

PEPT1 增强细菌肽转运至 LPS 处理的结肠上皮并诱导中性粒细胞募集

• 发表时间: 2019
• 作者: Watanabe Chikako;Inaba Kenichi;Sugihara Nao;Wada Akinori;Hanawa Yoshinori;Horiuchi Kazuki;FuruhashiHirotaka;Kurihara Chie;Okada Yoshikiyo;Shibuya Naoki;Higashiyama Masaaki;Tomita Kengo;Miura Soichiro;Hokari Ryota
• 通讯作者: Hokari Ryota

PEPT1 facilitates bacterial derived peptide transport into LPS-treated colonic epithelium and induces neutrophil recruitment

PEPT1 促进细菌源性肽转运至 LPS 处理的结肠上皮并诱导中性粒细胞募集

• 发表时间: 2018
• 作者: Chikako Watanabe;Soihiro Miura;Ryota Hokari
• 通讯作者: Ryota Hokari

Increased Basophil recruitment to the colon of UC patients and oxazolone-induced mice colitis

UC 患者和恶唑酮诱导的小鼠结肠炎结肠中嗜碱性粒细胞募集增加

• 发表时间: 2019
• 作者: Kenichi Inaba;Chikako Watanabe;et al
• 通讯作者: et al

Nicotine Ameliorates Colonic Inflammation via Inhibition of Leukocyte Interaction to Colonic Microvessels and Down-Regulation of MAdCAM-1

尼古丁通过抑制白细胞与结肠微血管的相互作用和下调 MAdCAM-1 来改善结肠炎症

• 发表时间: 2017
• 作者: Koji Maruta;Chikako Watanabe;Soichiro Miura;Ryota Hokari
• 通讯作者: Ryota Hokari