Novel therapeutic strategy for ovarian cancer targeting immune tolerance-inducing molecules, PD-L1 and IDO, using genome editing technique
Novel therapeutic strategy for ovarian cancer targeting immune tolerance-inducing molecules, PD-L1 and IDO, using genome editing technique
批准号:
17K11293
负责人:
INO KAZUHIKO
金额:
$3.0万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2017
资助国家:
日本
项目状态:
已结题
起止时间:
2017-04-01 至 2020-03-31
中文摘要
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英文摘要
期刊论文(0)
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PD-L1 disruption by CRISPR/Cas9-mediated genome editing in tumor cells promote antitumor immunity and suppress ovarian cancer progression in a mouse model
CRISPR/Cas9 介导的肿瘤细胞基因组编辑对 PD-L1 的破坏可促进小鼠模型中的抗肿瘤免疫并抑制卵巢癌的进展
DOI:
--
发表时间:
2018
期刊:
影响因子:
--
作者:
[Tamaki Yahata, Naoyuki Iwahashi, Mika Mizoguchi, Saori Toujima, Tsuneyasu Kaisho, Toshikazu Kondo, Kazuhiko Ino]
通讯作者:
Kazuhiko Ino
Usefulness of the primary tumor SUVmax on preoperative FDG-PET/CT as a prognostic indicator for patients with gynecologic cancers
术前 FDG-PET/CT 上原发肿瘤 SUVmax 作为妇科癌症患者预后指标的有用性
DOI:
--
发表时间:
2017
期刊:
J Clin Obstet Gynecol Infertility
影响因子:
--
作者:
[Ino K, Yahata T, Horiuchi Y, Yagi S]
通讯作者:
Yagi S
CRISPR/Cas9-mediated genome editing and efficient PD-L1 disruption on tumor cells promote antitumor immunity and suppress ovarian cancer progression in a mouse model
CRISPR/Cas9介导的基因组编辑和对肿瘤细胞的有效PD-L1破坏可促进小鼠模型中的抗肿瘤免疫并抑制卵巢癌进展
DOI:
--
发表时间:
2018
期刊:
影响因子:
--
作者:
[Tamaki Yahata, Naoyuki Iwahashi, Mika Mizoguchi, Madoka Yamamoto, Noriyuki, Sasaki, Michihisa Shiro, Yasushi Mabuchi, Shigetaka Yagi, Sawako Minami, Kazuhiko Ino]
通讯作者:
Kazuhiko Ino
PD-L1 disruption by CRISPR/Cas9-mediated genome editing in tumor cells promotes antitumor immunity and suppresses ovarian cancer progression in a mouse model
CRISPR/Cas9 介导的肿瘤细胞基因组编辑对 PD-L1 的破坏可促进小鼠模型中的抗肿瘤免疫并抑制卵巢癌的进展
DOI:
--
发表时间:
2017
期刊:
影响因子:
--
作者:
[Yahata T, Mizoguchi M, Ino K et al.]
通讯作者:
Ino K et al.
海外基金