Preparation of stretchable collagen hydrogels introduced by supramolecular cross-linkers

作为植入材料，水凝胶要求具有较高的力学性能和生物相容性。为了满足这些要求，在明胶水凝胶中引入了羧甲基醚基改性聚轮烷(CME-PRX)。首先，与EDC/NHS相比，CME-PRXs交联的明胶水凝胶不仅延伸性和韧性显著提高，而且其滞后性能也有显著改善。其次，与EDC/NHS交联明胶水凝胶相比，明胶水凝胶也具有细胞相容性，拉伸状态下α-CD在明胶水凝胶上的螺纹数可以调节明胶水凝胶上的细胞取向。证实了CME-PRXs交联明胶水凝胶可以作为植入材料。

As implant materials, high mechanical properties of hydrogels and biocompatibility are required. To accomplish these requirements, carboxymethyl ether group-modified polyrotaxanes (CME-PRXs) were introduced to gelatin hydrogels. Firstly, not only stretchability and toughness but also hysteresis in gelatin hydrogels cross-linked by CME-PRXs were significantly improved than those of EDC/NHS. Next, the gelatin hydrogels cross-linked CME-PRXs also had cytocompatibility compared to EDC/NHS-cross-linked gelatin hydrogels and the cellular orientation on gelatin hydrogels could be regulated by the threaded number of α-CDs onto CME-PRXs under stretching state. It was verified that gelatin hydrogels cross-linked by CME-PRXs can be applied as implant materials.