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Preparation of stretchable collagen hydrogels introduced by supramolecular cross-linkers

超分子交联剂引入可拉伸胶原水凝胶的制备

基本信息

批准号：
18J14112
负责人：
LEE Daehoon
金额：
$ 1.34万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for JSPS Fellows
财政年份：
2018
资助国家：
日本
起止时间：
2018-04-25 至 2020-03-31
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18J14112/
关键词：
Hysteresis loss Stretchable hydrogels Slide-ring gels Cell orientation Polyrotaxane Gelatin Stretchable hydrogel Slide-ring gel

项目摘要

As implant materials, high mechanical properties of hydrogels and biocompatibility are required. To accomplish these requirements, carboxymethyl ether group-modified polyrotaxanes (CME-PRXs) were introduced to gelatin hydrogels. Firstly, not only stretchability and toughness but also hysteresis in gelatin hydrogels cross-linked by CME-PRXs were significantly improved than those of EDC/NHS. Next, the gelatin hydrogels cross-linked CME-PRXs also had cytocompatibility compared to EDC/NHS-cross-linked gelatin hydrogels and the cellular orientation on gelatin hydrogels could be regulated by the threaded number of α-CDs onto CME-PRXs under stretching state. It was verified that gelatin hydrogels cross-linked by CME-PRXs can be applied as implant materials.

作为植入材料，要求水凝胶具有高的机械性能和生物相容性。为了实现这些要求，将羧甲基醚基团修饰的聚轮烷（CME-PRXs）引入明胶水凝胶中。首先，CME-PRXs交联的明胶水凝胶的拉伸性和韧性以及滞后性都比EDC/NHS交联的明胶水凝胶有显著改善。与EDC/NHS交联明胶水凝胶相比，CME-PRXs交联明胶水凝胶也具有细胞相容性，并且明胶水凝胶上的细胞取向可以通过拉伸状态下CME-PRXs上的α-CD的螺纹数量来调节。证实了通过CME-PRX交联的明胶水凝胶可用作植入材料。