FOR 521: Regulation of Immunological Processes by Membrane Proximal Signaling Modules

FOR 521：膜近端信号模块对免疫过程的调节

• 批准号: 5470521
• 金额: --
• 依托单位: Institut für Molekulare und Klinische Immunologie
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2003
• 资助国家: 德国
• 起止时间: 2002-12-31 至 2010-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5470521?language=en
• 关键词: 521; Regulation; Immunological; Processes; Membrane

The Research Unit aims at elucidating the molecular mechanisms underlying receptor-mediated activation and differentiation events within immunocompetent cells. Within the research group three major aspects of immune cell functions will be investigated. Four projects assess the molecular basis of immunoreceptor-mediated signal transduction. Here the functions of new transmembrane and cytosolic adapter proteins will be investigated by applying modern techniques in biochemistry, molecular biology and cell biology. Several knock-out models have been established which will facilitate the research within this focus.

该研究单位的目的是阐明免疫活性细胞内受体介导的活化和分化事件的分子机制。在研究小组内，将研究免疫细胞功能的三个主要方面。四个项目评估免疫受体介导的信号转导的分子基础。本文将应用生物化学、分子生物学和细胞生物学的现代技术研究新的跨膜和胞质衔接蛋白的功能。已经建立了几个敲除模型，这将有助于这一重点的研究。