SPP 1110: Innate Immunity

先天免疫包括一个由细胞和可溶性因子组成的网络，在最初的几个小时和几天里保护宿主免受病原微生物的侵袭。先天免疫的第二个重要作用是建立启动适应性、抗原特异性免疫反应的框架。通过先天免疫系统的不同组成部分在空间和时间上的协调作用，病原体来源的抗原的初始摄取和处理在为平衡的适应性免疫反应奠定基础方面发挥着关键作用。“先天免疫”优先方案汇集了分散在不同领域的专家，集中于四个研究专题：(1)被先天免疫系统认定为“外来”的病原体相关模式的鉴定和结构功能表征；(2)对先天免疫系统细胞表达的对启动和协调先天免疫反应和随后的适应性免疫反应至关重要的模式识别受体的鉴定和结构功能表征；(3)调节先天免疫系统的细胞内和细胞间效应机制；(4)先天免疫在传染病免疫发病机制中的作用。以基础科学为导向的优先计划旨在加深我们对触发天然免疫的分子成分的功能作用的理解，以提供调节天然免疫和获得性免疫反应的特定效应机制的信号。

Innate immunity comprehends a network of cells and soluble factors that defend the host in the first hours and days against invading pathogenic microorganisms. A second important role of innate immunity is to establish a framework for the inititation of an adaptive, antigen-specific immune response. The initial uptake and processing of pathogen-derived antigens through a spatially and temporally coordinated action of diverse components of the innate immune system plays a pivotal role in setting the stage for a balanced adaptive immune response. The priority programme "Innate Immunity" brings together geographically dispersed experts in the various fields to focus on four research topics:(1) Identification and structural-functional characterization of pathogen-associated patterns that are recognized by the innate immune system as "foreign",(2) Identification and structural-functional characterization of pattern recognition receptors expressed by cells of the innate immune system that are pivotal to the initiation and coordination of the innate and subsequent adaptive immune response,(3) Regulation of intra- and intercellular effector mechanisms of the innate immune system,(4) The role of innate immunity for the immunopathogenesis of infectious disease. The basic science-oriented priority programme is meant to further our understanding of the functional roles of molecular components triggering innate immunity to provide signals that regulate particular effector mechanisms of both innate and adaptive immune responses.