权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Cellular resolution macro analysis tools for functional and structural brain imaging

用于功能和结构脑成像的细胞分辨率宏观分析工具

基本信息

批准号：
21K12665
负责人：
KASARAGOD DEEPAKAMATH
金额：
$ 2.66万
依托单位：
Hiroshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2021
资助国家：
日本
起止时间：
2021-04-01 至 2024-03-31
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K12665/
关键词：
optical imaging 3d brain imaging fluorescence microscopy neuroinformatics brain imaging fluorescence microscope 3D imaging

项目摘要

The purpose of the proposed research was to develop open source microscopy tools for 3D brain imaging using novel light source for fluorescence microscopy in the deep ultraviolet spectrum.In FY2021, a prototypical fluorescence microscope for automated serial slicing and high resolution widefield block-face imaging across the whole brain or tissue block of interest was successfully developed. A manuscript submitted on the technical aspects is currently in second phase of revision.In FY2022, the applications for quantitative analysis was carried out on normal mouse brains. The study is running smoothly as expected.

这项研究的目的是开发开源的3D脑成像工具，使用新的光源进行深紫外光荧光显微镜成像。在2021财年，成功地开发了一台原型荧光显微镜，用于全脑或感兴趣组织块的自动连续切片和高分辨率宽视场块面成像。目前提交的关于技术方面的手稿正在进行第二阶段的修订。在2022财年，对正常小鼠的大脑进行了定量分析的申请。研究进展顺利，不出所料。