Development of bone regeneration methods based on understanding of tissue remodeling

基于对组织重塑的理解开发骨再生方法

• 批准号: 21K19883
• 负责人: Tei Yuichi
• 金额: $ 3.99万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Research (Exploratory)
• 财政年份: 2021
• 资助国家: 日本
• 起止时间: 2021-07-09 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K19883/
• 关键词: 組織リモデリング; バイオマテリアル; 骨再生; 線維化; 一細胞解析; 骨欠損

项目成果

Elucidating Gene Regulatory Networks Underlying Human Skeletal Development by Integrating a Model of Human Endochondral Bones and Single-cell Multiomics

通过整合人类软骨内骨模型和单细胞多组学来阐明人类骨骼发育背后的基因调控网络

• 发表时间: 2022
• 作者: Shoichiro Tani;Hiroyuki Okada;Masahide Seki;Yutaka Suzuki;Taku Saito;Sakae Tanaka;Ung-il Chung;Hironori Hojo and Shinsuke Ohba
• 通讯作者: Hironori Hojo and Shinsuke Ohba

Induction and expansion of human PRRX1+ limb-bud-like mesenchymal cells from pluripotent stem cells

• DOI: 10.1038/s41551-021-00778-x
• 发表时间: 2021-08-09
• 期刊: NATURE BIOMEDICAL ENGINEERING
• 影响因子: 28.1
• 作者: Yamada, Daisuke;Nakamura, Masahiro;Takarada, Takeshi
• 通讯作者: Takarada, Takeshi

"Gene regulatory networks underlying human endochondral bone formation "

“人类软骨内骨形成的基因调控网络”

• 发表时间: 2022
• 作者: Shoichiro Tani;Hiroyuki Okada;Taku Saito;Sakae Tanaka;Ung-il Chung;Hironori Hojo and Shinsuke Ohba
• 通讯作者: Hironori Hojo and Shinsuke Ohba

Simple Preparation of Injectable Hydrogels with Phase-Separated Structures That Can Encapsulate Live Cells

• DOI: 10.1021/acsami.2c09906
• 发表时间: 2022-07-26
• 期刊: ACS APPLIED MATERIALS & INTERFACES
• 影响因子: 9.5
• 作者: Ishikawa, Shohei;Yoshikawa, Yuki;Sakai, Takamasa
• 通讯作者: Sakai, Takamasa

Understanding a Mechanism Underlying Bone Repair Process by Combinational Analysis of Lineage Tracing and Single-Cell RNA Sequencing

通过谱系追踪和单细胞 RNA 测序的组合分析了解骨修复过程的潜在机制

• 发表时间: 2021
• 作者: Mika Nakayama;Hiroyuki Okada;Masahide Seki;Yutaka Suzuki;Ung-il Chung;Shinsuke Ohba;Hironori Hojo
• 通讯作者: Hironori Hojo