FOR 1036: Mechanisms, Functions and Evolution of Wnt-signalling Pathways

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This Research Unit focusses on the analysis of the Wnt-signalling network. This regulator module is essential for embryonic development and is responsible for a number of human diseases. The signalling event triggered by Wnt-type growth factors are competitive research filed with high relevance for biological and medical research. Eight groups, which work on different aspects of Wnt-signalling joined the Research Unit. The participating groups are affiliated with the University of Heidelberg (T. Holstein, zoology; S. Özbek, zoology; S. Hardt, Cardiology; H. Steinbeisser, human genetics), the University of Karlruhe (D. Wedlich, zoology; D. Gradl, zoology) and with the German Cancer Research Center (DKFZ) Heidelberg (M. Boutros; C. Niehrs). The Research Unit addresses the following questions: How are Wnt-proteins modified, secreted and how do they form activity gradients? How do components of the Wnt-signalling cascade interact inside and outside the cell? What are the roles of Wnt-signalling molecules in organ formation and remodelling? The Research Unit uses a structure function approach, which requires an arsenal of techniques from biochemistry, structural biology, cell biology and physiology. The members contribute a very complementary set of expertise and experimental models. In this context the animal/embryo models (Hydra/Nematostella; Drosophila, Xenopus und mouse) used by members of the Research Unit are of particular importance.