Rewiring the brain: remote-controlled axon guidance by magnetic nanoparticles to improve Parkinson's therapies

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Within the first year of the grant, various important steps were performed that serve as the prerequisite and basis for the project. 1) Suitable magnetic nanoparticles were acquired. Two types of nanoparticles turned out to be tolerated by the cells without any notable side effects. 2) The magnetic applicator was designed and built. The first 3D-printed version was unfortunately not successful. Therefore, two devices from aluminum were constructed. Now, these devices have an improved and more homogenous magnetic field. 3) The application of nanoparticles to dopaminergic progenitors was established and optimized. The most difficult part of the attachment of spheres is finally solved. 4) First magnetic manipulations are performed, and the optimization of different parameters is ongoing.