High-resolution spatiotemporal analysis of harmaline-induced tremor and inferior olive activity in living mice

点击翻译按钮获取中文摘要

In the past year, our dedicated research team has made noteworthy progress in elucidating the kinematic and neuromotor mechanisms of tremor-related disorders. We have successfully initiated a project to determine safe conditions for viral expression of GCamP6 in the inferior olive (IO), which plays a critical role in understanding harmaline-induced tremor in mice. This work's findings will be presented at the esteemed JNS conference in Sendai, August 2023. Concurrently, we expanded our experimental setup to assess harmaline-induced tremor in mice performing various motor tasks, such as high-speed locomotion, balancing, and 3D space exploration. Furthermore, we have integrated these intricate naturalistic behavior tasks with simultaneous recording of cerebellar nuclear activity, completing the initial full batch of experiments in April 2023. Our progress demonstrates our unwavering commitment to overcoming challenges in studying tremor-related disorders.