Analyses of in vivo neuroprotective role of STB/HAP1 against autonomic and motoneuron degeneration in the central and peripheral nervous system

在我们研究的第一年，我们阐明了STB/HAP1在成年小鼠脑干中的神经解剖学分布。我们还阐明了STB/HAP1与ChAT的关系，特别是自主神经和运动神经元的关系。我们的结果表明，脑神经运动核团可能比表达STB/HAP1的脑干核团更容易受到神经退行性应激的影响。此外，我们还明确了STB/HAP1在肠自主神经节和舌自主神经节中的表达。

In the first year of our study, we clarified the neuroanatomical distribution of STB/HAP1 in the brainstem of adult mice. We also elucidated the relationships of STB/HAP1 with ChAT, with particular emphasis on autonomic and motor neurons. Our results suggest that cranial nerve motor nuclei might be more vulnerable to neurodegenerative stresses than STB/HAP1-expressing brainstem nuclei. In addition, we clarified the STB/HAP1 expression in the enteric and tongue autonomic ganglia.