FOR 1041: Germ Cell Potential

FOR 1041：生殖细胞潜力

• 批准号: 58733678
• 金额: --
• 依托单位: Abteilung für Klinische und Operative Andrologie
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/58733678?language=en
• 关键词: 1041; Germ; Cell; Potential

The Research Unit will explore and exploit the potential of germ cells. It combines stem cell research and reproductive medicine. Using modern cellular and molecular techniques (stem cell culture, 2D and 3D microscopy, methylation analysis, expression profiling and proteomics), it will investigate the development and the decline of the germ cell potential during in vivo and in vitro gametogenesis. A major focus will be the genetic and epigenetic determinants of the germ cell potential. The projects will take advantage of the particular strengths of well-established animal models and clinical studies:

研究组将探索和利用生殖细胞的潜力。它结合了干细胞研究和生殖医学。利用现代细胞和分子技术（干细胞培养，2D和3D显微镜，甲基化分析，表达谱和蛋白质组学），它将研究在体内和体外配子发生过程中生殖细胞潜力的发展和下降。一个主要的焦点将是生殖细胞潜力的遗传和表观遗传决定因素。这些项目将利用成熟的动物模型和临床研究的特殊优势：