Novel anti-fibrotic properties of heme binding proteins including Neuroglobin, Myoglobin, and Hemoglobin in comparison with Cytoglobin in vitro and in vivo

我们已经探索了其他血红素结合蛋白，如血红蛋白（HB），肌红蛋白（MB）和神经红蛋白（NGB），它们也具有气体结合和ROS清除功能，显示出与CYGB相同的抗纤维化特性。与CYGB相比，人HB、MB和NGB的抗氧化和ROS清除功能以及调节其功能的结构改变已被检查。这些球蛋白的细胞内和组织内生物分布、动力学、安全性测定和抗纤维化功能在体外和体内均得到证实。

We have explored that other heme-binding proteins such as hemoglobin (HB), myoglobin (MB), and neuroglobin (NGB) which also possing the gas binding, and ROS scavenging function, have showed the same anti-fibrotic properties as CYGB. The antioxidant, and ROS scavenging function of human HB, MB, and NGB in comparison with CYGB as well as structure alteration regulating their function have been examined. Intra-cellular and tissue bio-distribution, the kinetics, safety assay, and anti-fibrotic function of these globins were demonstrated both in vitro and in vivo.