Elucidation of pathophysiology of non-pulmonary artery-derived atrial fibrillation based on genomic information and application to optimal treatment

基于基因组信息阐明非肺动脉源性房颤的病理生理学并应用于最佳治疗

• 批准号: 22K08184
• 负责人: 中野 由紀子
• 金额: $ 2.66万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2022
• 资助国家: 日本
• 起止时间: 2022-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K08184/
• 关键词: 心房細動; 非肺静脈起源; GWAS; 非肺動脈起源; ゲノム情報; 一塩基多型

発作性心房細動1013症例のうち、肺静脈から心房細動が誘発された症例を肺静脈起源と定義し、肺静脈以外から心房細動が誘発された症例を非肺静脈起源と定義した。非肺静脈起源を149例に肺静脈起源を864例に認めた。非肺静脈起源の起源としては上大静脈、左心房後壁、左心房前壁、心房中隔、室上陵、冠静脈洞などであった。臨床的指標としては、非肺静脈起源の症例の方が有意に若かった。GWASを用いた非肺静脈起源関連遺伝子の検出を目的として、発作性心房細動1013症例のGWASを行い、非肺静脈起源149例と肺静脈起源864例で比較を行った。その結果、18個の一塩基多型(SNP)がP<1e-5で示唆的有意性を示した。MAGMA Gene-Set Analysisを行い、IL6の制御に関わるGO-term(12個の遺伝子で構成される)が有意差を示した。

1013 cases of paroxysmal atrial exercise induced by paroxysmal atrial exercise, the definition of the origin of pulmonary static exercise, the definition of the origin of non-pulmonary static atrial exercise, the definition of non-pulmonary static atrial motion, the definition of non-pulmonary static origin, the definition of non-pulmonary static origin. There were 149 cases of non-pulmonary static origin and 864 cases of pulmonary static origin. The origin of non-pulmonary ventriculus, the posterior wall of the left atrium, the anterior wall of the left atrium, the atrial septum, the supraventricular tomb and the coronal cavity. The finger of the bed is not the origin of the lung, but the origin of the lung is not. GWAS was used to detect the origin of pulmonary arrhythmia in 1013 patients with paroxysmal atrial motion, 1013 patients with non-pulmonary static origin and 1013 patients with non-pulmonary static origin. The results showed that there were 18 cases of intentional sexual instigation of single gene polymorphisms (SNP). The MAGMA Gene-Set Analysis line and the IL6 control system are intended to show the difference between the GO-term (12 sub-models).