Elucidation of pathophysiology of non-pulmonary artery-derived atrial fibrillation based on genomic information and application to optimal treatment

基于基因组信息阐明非肺动脉源性房颤的病理生理学并应用于最佳治疗

• 批准号: 22K08184
• 负责人: 中野 由紀子
• 金额: $ 2.66万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2022
• 资助国家: 日本
• 起止时间: 2022-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K08184/
• 关键词: 心房細動; 非肺静脈起源; GWAS; 非肺動脈起源; ゲノム情報; 一塩基多型

発作性心房細動1013症例のうち、肺静脈から心房細動が誘発された症例を肺静脈起源と定義し、肺静脈以外から心房細動が誘発された症例を非肺静脈起源と定義した。非肺静脈起源を149例に肺静脈起源を864例に認めた。非肺静脈起源の起源としては上大静脈、左心房後壁、左心房前壁、心房中隔、室上陵、冠静脈洞などであった。臨床的指標としては、非肺静脈起源の症例の方が有意に若かった。GWASを用いた非肺静脈起源関連遺伝子の検出を目的として、発作性心房細動1013症例のGWASを行い、非肺静脈起源149例と肺静脈起源864例で比較を行った。その結果、18個の一塩基多型(SNP)がP<1e-5で示唆的有意性を示した。MAGMA Gene-Set Analysisを行い、IL6の制御に関わるGO-term(12個の遺伝子で構成される)が有意差を示した。

1013 symptoms of atrial fibrillation, pulmonary veins, atrial fibrillation, and pulmonary veins The origin is defined as origin other than the pulmonary veins, and the symptoms of atrial fine movement induced by other than the pulmonary veins are defined as non-pulmonary vein origins. Non-pulmonary vein origin was recognized in 149 cases and pulmonary vein origin in 864 cases. The origins of non-pulmonary veins include the superior great vein, the posterior wall of the left atrium, the anterior wall of the left atrium, the atrial septum, the superior ventricular ridge, and the coronary vein hole. The clinical indicators are as follows, and the prescriptions for cases of non-pulmonary vein origin are as follows. The results of GWAS were related to non-pulmonary vein origin, and the results of 1013 cases of atrial fibrillation, 149 cases of non-pulmonary vein origin, and 864 cases of pulmonary vein origin were compared. As a result, the intentionality of the 18 SNP polytypes (SNPs) with P<1e-5 is shown. MAGMA Gene-Set Analysisを行い, IL6's control and control, GO-term (12 の伝子で constituted by される), there is no intentional difference.