免疫チェックポイント阻害薬耐性克服を目指した新規動注免疫療法の開発

开发一种新型动脉内注射免疫疗法，旨在克服免疫检查点抑制剂耐药性

• 批准号: 22K10226
• 负责人: 光永 幸代
• 金额: $ 2.66万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2022
• 资助国家: 日本
• 起止时间: 2022-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K10226/
• 关键词: 動注; 免疫療法

口腔癌治療において、近年免疫チェックポイント阻害剤(ICI)が臨床応用され、生存期間の延長など目覚しい効果が見られているが、奏効率の低さが課題で、またいくつかの耐性機構が存在することが分かりつつある。そこで本研究ではトランスレーショナルリサーチとして、がん組織内に特異的に薬剤や細胞を還流できる超選択的動注法を応用し、活性化T細胞の組織内濃度を高める他、耐性を解除することが期待される薬剤をICIと併用投与することで、より副作用が少なく高い抗腫瘍効果が期待できる新しい治療法の確立を目的とする。その投与方法や薬剤分布などを検討し、近い将来の臨床応用を目指す。浅側頭動脈を用いた動注化学療法は本邦で共同開発されたもので、さらに後頭動脈を用いる事で同時2経路(左右合 わせて4経路)による投与を可能とした。よってこの超選択的動注法に標的治療薬を応用する研究は、例えば腫瘍中心部と腫瘍周辺部で標的を変えるなど、様々な応用が可能で学術的意義も高い。本研究ではがん組織内に特異的に薬剤を還流できる超選択的動注法を応用し、ICIの耐性機構を解除する薬剤と共にICIを投与することで、全身の免疫関連副作用が少なく高い抗腫瘍効果が期待される次世代の免疫療法の確立を目指す。

In the treatment of oral cancer, in recent years, immunological drugs have been used to block the use of ICI, the survival period has been prolonged, the performance rate has been low, and there has been a training program in the institutions of tolerance and tolerance. The purpose of this study is to improve the accuracy of the study. In this study, we do not know how to use the method of action in this study. In this study, we do not know how to do this research. In this study, we do not know that in this study, we do not know how to do this research. In this study, we do not know how to do this in this study. in this study, we use the method of activating T cells in the tissue to improve the quality of the tissue, and we expect that the ICI will be used in the tissue. There are fewer side effects, fewer side effects, higher levels of anti-drug, and we are looking forward to the new treatment to ensure the purpose of the treatment. In terms of investment and methods, we will use eyes in the near future. Using the chemical method of chemical injection, the local government will jointly open the train, and the train will be operated at the same time (4 miles between the left and the right) at the same time. The treatment of the super-selected motion note method, such as the study of the use of medicine, the central part of the department, the meaning of the science of possibility and the meaning of the science of possibility. The purpose of this study is to investigate the use of the action method of the super-selected anti-virus in the tissue, the mechanism of ICI tolerance, the injection of ICI and the reduction of the side effects of systemic immunity. The results show that the target is confirmed by the next generation of immunoassay.