Molecular-Scale Interaction of Nanomaterials with Biomembranes

纳米材料与生物膜的分子尺度相互作用

• 批准号: DE220100511
• 负责人: A/Prof Aaron Elbourne
• 金额: $ 32.37万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE220100511
• 关键词: Molecular; Scale; Interaction; Nanomaterials; Biomembranes

This project aims to develop a holistic understanding of how nanoparticles, and nanomaterials in general, interact with cellular materials, via the cell membrane on a molecular level. To date, the precise mechanism by which nanomaterials, such as particles, colloids, and sheets, interact with cellular material is poorly understood. This project expects to generate new, fundamental knowledge in the field, and establish a platform for high-resolution, in situ, molecular-scale imaging of nanoscale events at the biomembrane. This will develop a fundamental understanding of the dynamics of nanomaterial-cell interactions, and provide benefit in the development of next-generation nanomaterial-based therapeutics and diagnostic technologies.

该项目旨在全面了解纳米颗粒和纳米材料如何在分子水平上通过细胞膜与细胞材料相互作用。到目前为止，纳米材料，如颗粒，胶体和片材，与细胞材料相互作用的确切机制知之甚少。 该项目预计将在该领域产生新的基础知识，并建立一个平台，用于生物膜纳米级事件的高分辨率，原位，分子尺度成像。这将发展对纳米材料-细胞相互作用动力学的基本理解，并为开发下一代基于纳米材料的治疗和诊断技术提供益处。