Understanding nutritional interactions for targeted microbiome manipulation

了解营养相互作用以进行有针对性的微生物组调控

• 批准号: DE220100965
• 负责人: Dr Vanessa Rossetto Marcelino
• 金额: $ 31.98万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-05-01 至 2026-05-13
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE220100965
• 关键词: Understanding; nutritional; interactions; targeted; microbiome

This project aims to identify how microbial communities, known as microbiomes, can be effectively manipulated to the benefit of their host. Microbiome manipulation has been in the spotlight as a potential solution to maintain or improve the health of several hosts, from threatened coral species to livestock and humans, but the development of industry-scale strategies has been slow. This project proposes to chart the nutritional interactions among microorganisms and to identify cascade effects of microbiome manipulation. This will generate fundamental knowledge on the biological processes underlying community stability and malleability, which will ultimately help engineering optimised microbiomes.

该项目旨在确定如何有效地操纵微生物群落（称为微生物组）以使其宿主受益。微生物组操纵一直是人们关注的焦点，因为它是维持或改善从受威胁的珊瑚物种到牲畜和人类等几种宿主健康的潜在解决方案，但工业规模战略的发展一直缓慢。该项目旨在绘制微生物之间的营养相互作用，并确定微生物组操作的级联效应。这将产生关于社区稳定性和可塑性的生物过程的基础知识，这将最终帮助工程优化微生物组。