Arrays of Amphiphilic Metal Complexes for Guided Molecular Recognition at Interfaces

用于界面引导分子识别的两亲性金属配合物阵列

• 批准号: 72989059
• 负责人: Professor Dr. Burkhard König
• 金额: --
• 依托单位: Institut für Organische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2011-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/72989059?language=en
• 关键词: Arrays; Amphiphilic; Metal; Complexes; Guided

Functionalized interfaces are of interest as sensors or sophisticated materials, but their defined preparation is still a challenge. In this project we combine the technique of double layer preparation from self-assembled monolayers and ultrathin Langmuir Blodgett films, which allows a high in-plane control of steric conditions, with amphiphilic metal complex binding sites, providing specific and high affinity to certain functional groups in aqueous media. The so obtained surfaces of ordered metal complex binding sites are used for guided self-assembly of nucleotides in additional layers yielding highly complex, but well defined surface structures. The dependence of the assembly process on the surface structure is explored by modification of the metal complex binding sites and their arrangement in the interface, and by the use of different nucleotides and oligonucleotides for the guided assembly on the surface. With more than one kind of binding site embedded in the surface, the formation of surface patterns becomes possible. Such surfaces may show enhanced binding selectivities. We will explore the effect of different layer compositions on the binding on surface and use template molecules to preorganize binding sites during the layer formation process. Reactive diacetylene amphiphiles allow retaining assembled patterns in a polydiacetylene film.

功能化的界面作为传感器或复杂材料是很有意义的，但它们的特定准备仍然是一个挑战。在这个项目中，我们结合了由自组装单分子膜和超薄的朗缪尔布洛吉特薄膜制备双层膜的技术，这种技术允许在平面内高度控制空间条件，具有两亲性的金属络合物结合部位，为水介质中的某些官能团提供了特异性和高亲和力。如此获得的有序金属络合物结合位点的表面被用于在额外的层中引导核苷酸的自组装，从而产生高度复杂但定义良好的表面结构。通过修饰金属络合物结合部位及其在界面上的排列，以及使用不同的核苷酸和寡核苷酸在表面进行引导组装，探索了组装过程对表面结构的依赖关系。由于表面嵌入了不止一种结合部位，表面图案的形成成为可能。这种表面可以表现出增强的结合选择性。我们将探索不同的层组成对表面结合的影响，并在层形成过程中使用模板分子预组织结合部位。反应性双乙炔两亲物允许将组装的图案保留在聚二乙炔薄膜中。