Arrays of Amphiphilic Metal Complexes for Guided Molecular Recognition at Interfaces

用于界面引导分子识别的两亲性金属配合物阵列

• 批准号: 72989059
• 负责人: Professor Dr. Burkhard König
• 金额: --
• 依托单位: Institut für Organische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2011-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/72989059?language=en
• 关键词: Arrays; Amphiphilic; Metal; Complexes; Guided

Functionalized interfaces are of interest as sensors or sophisticated materials, but their defined preparation is still a challenge. In this project we combine the technique of double layer preparation from self-assembled monolayers and ultrathin Langmuir Blodgett films, which allows a high in-plane control of steric conditions, with amphiphilic metal complex binding sites, providing specific and high affinity to certain functional groups in aqueous media. The so obtained surfaces of ordered metal complex binding sites are used for guided self-assembly of nucleotides in additional layers yielding highly complex, but well defined surface structures. The dependence of the assembly process on the surface structure is explored by modification of the metal complex binding sites and their arrangement in the interface, and by the use of different nucleotides and oligonucleotides for the guided assembly on the surface. With more than one kind of binding site embedded in the surface, the formation of surface patterns becomes possible. Such surfaces may show enhanced binding selectivities. We will explore the effect of different layer compositions on the binding on surface and use template molecules to preorganize binding sites during the layer formation process. Reactive diacetylene amphiphiles allow retaining assembled patterns in a polydiacetylene film.

功能化界面作为传感器或复杂材料是令人感兴趣的，但其定义的制备仍然是一个挑战。在这个项目中，我们结合联合收割机的双层制备技术，从自组装单分子膜和LB膜，它允许一个高度的平面内控制的空间条件，与两亲性金属络合物结合位点，提供特定的和高亲和力的某些功能基团在水介质中。如此获得的有序金属络合物结合位点的表面用于在额外的层中引导核苷酸的自组装，产生高度复杂但明确定义的表面结构。的表面结构上的组装过程的依赖性进行了探讨，通过修改的金属络合物的结合位点和它们在界面中的排列，并通过使用不同的核苷酸和寡核苷酸的表面上的引导组装。随着一种以上的结合位点嵌入表面，表面图案的形成成为可能。这样的表面可以显示出增强的结合选择性。我们将探讨不同的层组成对表面结合的影响，并在层形成过程中使用模板分子来预组织结合位点。反应性二乙炔两亲物允许在聚二乙炔膜中保留组装的图案。