Oral nanoparticle formulations for allergy treatment via efficient induction of immune tolerance

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The aim of this year's research was to improve the tolerogenic nanoparticle(tNP) for inducing immune tolerance and preventing allergic reactions.1. Through research on the preparation of the tNP, size control, and dissolution experiments, we successfully determined the basic properties of the tNP in this year.2. Regarding the interaction between tNP and cells, through co-culture observations with BMDCs, we confirmed that the tNP can be phagocytosed by BMDCs and can change the differentiation direction of BMDCs. Additionally, we confirmed that the tNP has certain T cell stimulation capability, which are crucial for establishing immune tolerance.3. In terms of animal experiments, we conducted safety evaluation and confirmed the safety of the tNP without causing anaphylaxis. Subsequently, we applied the tNP in prevention experiments on OVA allergy model mice. The experimental results showed that the tNP can effectively prevent allergic reactions. This means that the tNP we developed can become a new type of allergy treatment.The significance of this research lies in inducing immune tolerance through tNP preparation to prevent allergic reactions without affecting normal immune responses. Compared to traditional allergy treatment methods, tNP has the advantages of being easy to prepare and quick to take effect, which can greatly improve the convenience of patient treatment and quality of life. Overall, the research results of this year provide a new idea and method for immune tolerance research and allergy treatment, with potential application value in clinical treatment.