Novel Function Investigation of Coagulation Factors in Defense System Regarding Infection: From Medaka (Oryzias latipes) to Human (Homo sapiens)

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In my research, I use Japanese medaka, a popular model organism in research field, to study the relationship between the blood coagulation (blood clot formation) and immunity. Last year, I successfully established the fibrinogen gene-deficient medaka which cannot form normal blood clot. Meanwhile, I tried to induce the bacterial infection to medaka aim to study the immune system in medaka. During the infection study, I found in infected medaka blood sample, more string-like structures were observed, and these structures are considered as the extracellular traps (ETs) which is an innate immune response upon stimulant in human. The existence and mechanisms of ETs in medaka is still unclear. Therefore, investigation of medaka ETs is a new knowledge in medaka immune study and can also provide new viewpoint for related diseases’ treatment in human.