バイオミメティックポリエン環化反応に有効な超分子触媒の設計

有效仿生多烯环化反应的超分子催化剂设计

• 批准号: 22KJ1613
• 负责人: HUANG Jianhao
• 金额: $ 1.6万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for JSPS Fellows
• 财政年份: 2023
• 资助国家: 日本
• 起止时间: 2023-03-08 至 2025-03-31
• 项目状态: 未结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22KJ1613/
• 关键词: polyene cyclization; LBA catalyst system; asymmetric synthesis

At the base of the previous work of catalyst design in carbonyl-ene cyclization & tandem acetalization, we are exploring the proper catalyst systems for the asymmetric polyene cyclization. At first, we are focusing on the design of the LBA catalyst for the cyclization in the single-ring formation and wish to further expand it to the polyenes or functional polyenes in the near future. We’ve explored several combinations of the chiral phosphoric acids with diverse Lewis acids to examine the reaction below. So far, we’ve already succeeded the excellent E/Z selectivity and moderate enantioselectivity in the initial screening of the standard reaction.

本文在前人研究工作的基础上，对不对称多烯环化反应的催化剂体系进行了探索。首先，我们专注于设计用于单环形成环化的LBA催化剂，并希望在不久的将来将其进一步扩展到多烯或功能多烯。我们已经探索了手性磷酸与不同刘易斯酸的几种组合，以检查下面的反应。到目前为止，我们已经在标准反应的初步筛选中获得了良好的E/Z选择性和中等的对映体选择性。