Targeting selective host-guest interactions in functionalized MOFs - synthesis, NMR-studies and sensor design

金属-有机骨架代表了一类用途广泛的多孔材料，其与客体分子的相互作用原则上可以通过改变有机连接物分子的性质以及组成金属离子的配位环境来控制。该项目旨在了解和控制MOF中的主客体相互作用，这将通过有机连接物分子的官能化来实现。引入定位良好的特定功能有望提供许多重要的优势，包括在具有相似总体性质的同一类MOF中主客体相互作用的变化，以及独立于主体晶格的结构设计选择性相互作用的能力。根据第一个资助期的结果，该项目将专注于自然界中发现的具有双氢键和三氢键模式的锚。它们提供与碱基和巴比妥酸盐等重要生物分子的锁键相互作用。通过这一点，有望建立一系列有希望的受体用于传感器研究。该联盟的合作伙伴都为该项目带来了互补的技能和背景，从分子构建块的合成到新MOF结构的合成和功能化，分子主客体相互作用的详细物理化学研究，到新型MOF基薄膜和MOF基布拉格堆栈的生长和研究，这些都将被探索为选择性化学传感的新概念的基础。

Metal-organic frameworks represent a highly versatile class of porous materials whose interactions with guest molecules can be controlled, in principle, by varying the nature of the organic linker molecules as well as the coordination environment of the constituting metal ions. This project aims at the understanding and control of host-guest interactions in MOFs, which will be achieved through functionalization of the organic linker molecules. Introducing well-positioned specific functionalities is anticipated to provide a number of important advantages including the variation of host-guest interactions in the same class of MOFs with similar overall properties and the ability to design selective interactions independent from the construction of the host lattice. Based on results of the first funding period, the project will concentrate on anchors with double and triple hydrogen bond patterns found in nature. They provide lock-key interactions with important biomolecules like nucleobases and barbiturates. By this it is anticipated to built-up a series of promising receptors for sensor studies. The partners in this consortium all bring complementary skills and background to the project, ranging from synthesis of molecular building blocks to the synthesis and functionalization of new MOF structures, the detailed physicochemical study of molecular host-guest interactions, to the growth and investigation of novel MOF-based thin films and MOF-based Bragg stacks, which will be explored as the basis for novel concepts in selective chemical sensing.