Targeting selective host-guest interactions in functionalized MOFs - synthesis, NMR-studies and sensor design

金属-有机骨架代表了一类高度通用的多孔材料，其与客体分子的相互作用原则上可以通过改变有机连接分子的性质以及构成金属离子的配位环境来控制。该项目旨在理解和控制MOFs中的主客体相互作用，这将通过有机连接分子的功能化来实现。引入良好定位的特定功能预计将提供许多重要的优点，包括在具有相似的整体性质的同一类MOF中的主-客体相互作用的变化，以及设计独立于主体晶格的构造的选择性相互作用的能力。根据第一个资助期的结果，该项目将集中研究自然界中发现的具有双氢键和三氢键模式的锚。它们提供与重要生物分子如核碱基和巴比妥酸盐的锁钥相互作用。这为建立一系列具有应用前景的传感器受体奠定了基础。该联盟的合作伙伴都为该项目带来了互补的技能和背景，从分子构建块的合成到新MOF结构的合成和功能化，分子主客体相互作用的详细物理化学研究，到新型MOF基薄膜和基于MOF的布拉格堆栈的生长和研究，这些都将被探索为选择性化学传感新概念的基础。

Metal-organic frameworks represent a highly versatile class of porous materials whose interactions with guest molecules can be controlled, in principle, by varying the nature of the organic linker molecules as well as the coordination environment of the constituting metal ions. This project aims at the understanding and control of host-guest interactions in MOFs, which will be achieved through functionalization of the organic linker molecules. Introducing well-positioned specific functionalities is anticipated to provide a number of important advantages including the variation of host-guest interactions in the same class of MOFs with similar overall properties and the ability to design selective interactions independent from the construction of the host lattice. Based on results of the first funding period, the project will concentrate on anchors with double and triple hydrogen bond patterns found in nature. They provide lock-key interactions with important biomolecules like nucleobases and barbiturates. By this it is anticipated to built-up a series of promising receptors for sensor studies. The partners in this consortium all bring complementary skills and background to the project, ranging from synthesis of molecular building blocks to the synthesis and functionalization of new MOF structures, the detailed physicochemical study of molecular host-guest interactions, to the growth and investigation of novel MOF-based thin films and MOF-based Bragg stacks, which will be explored as the basis for novel concepts in selective chemical sensing.