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The study for the development of quality-of-life (QOL) assessment methods in cancer treatments ant its application to the practical medicine

癌症治疗中生活质量（QOL）评估方法的发展及其在实际医学中的应用研究

基本信息

批准号：
09672309
负责人：
SHIMOZUMA Kojiro
金额：
$ 1.34万
依托单位：
KAWASAKI MEDICAL SCHOOL
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

项目摘要

1.Translations of the quality-of-life (QOL) questionnaires developed in western countries which were frequently used in many cancer clinical trials and their cross-cultural validation(1)The translations of the EORTC QLQ-BR23 (breast cancer subscale), FACT-B (breast cancer subscale), and FACT-Taxane were completed. They are used in a phase III ranndomized trials comparing two types of post-surgial adjuvant chemotherapy for breast cancer patient (NSAS-BC).(2)Semi-fical translations of the FACT-Sp (spiritual well-being), 0 (ovarian cancer), Cx (cervical cancer), C (colorectal cancer), P (pancreas cancer). E (seophageal cancer), ACT (anorexiafcachexia), and ES (estrogen-related symptoms) were completed. They are in the process of pilot-testing.2.The results of the psychometric properties (acceptability, reliability, validity, and sensitivity) of the two QOL questionnaire measures, that is, EORTC QLQ-C30 and the QOL-ACD, for Japanese cancer patients will be presented in the 35th Annual Meeting of the American Society fo Clinical Oncology (ASCO) and the 7th Annual Meeting of the Japanese Breast Cancer Society in May, 1999. Papers onthese subjects will be submitted in a near future.3.The results of the detailed assessnents of treatment-related symptoms, psychological destress, and QOL in post-surgical breast cancer patients in Los Angels, and the analyses of predictive factors of their QOL were reported in a paper (Breast Cancer Res and Treat, in press). We geban similar study for Japanese patients.4.The paper investigating the prognostic significance of QOL scores is in submission.5.We began the study investigating the risk and and benefit of beast cancer patients receiving adjuvant therapies using Markov decision models in which patients-administered QOL scores assessed by EuroQol, FACT, and Time Trade-off (TTO) will be imputed. The endpoint of the study is cost/QALY (Quality-adjusted life year).

1.翻译西方国家开发的生活质量（QOL）问卷，这些问卷经常用于许多癌症临床试验及其跨文化验证（1）完成EORTC QLQ-BR 23（乳腺癌子量表）、FACT-B（乳腺癌子量表）和FACT-Taxane的翻译。它们用于比较两种类型的乳腺癌患者手术后辅助化疗（NSAS-BC）的III期随机试验。（2）FACT-Sp（spiritual well-being）、0（ovarian cancer）、Cx（cervical cancer）、C（colorectal cancer）、P（pancreatic cancer）的半虚构翻译。完成了E（食管癌）、ACT（恶病质）和ES（雌激素相关症状）。2.心理测量学性质的研究结果将在5月举行的第35届美国临床肿瘤学会（ASCO）年会和第7届日本乳腺癌学会年会上介绍日本癌症患者的两种QOL问卷测量（即EORTC QLQ-C30和QOL-ACD）的可接受性、可靠性、有效性和敏感性，1999. 3.对洛杉矶乳腺癌术后患者的治疗相关症状、心理压力和生活质量进行了详细的评估，并对其生活质量的预测因素进行了分析。我们对日本患者进行了类似的研究。4.研究QOL评分的预后意义的论文正在提交中。5.我们开始了使用Markov决策模型研究接受辅助治疗的乳腺癌患者的风险和获益的研究，其中将插补通过EuroQol、FACT和时间权衡（TTO）评估的患者给予的QOL评分。该研究的终点是成本/QALY（质量调整生命年）。