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Study on Thrapeutic Drug Monitoring Simulation Program

治疗药物监测模拟程序研究

基本信息

批准号：
09672321
负责人：
SHIMIZU Sakae
金额：
$ 0.51万
依托单位：
Kanazawa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09672321/
关键词：
drug information design of medication suitable and good drug usage blood concentration simulating program stand-alone type informing sheet medical and pharmaceutical infomatics 医薬品適性使用教育用プログラム双方向性プログラム

项目摘要

Recently, computing envilopments have been developed rapidly in both hardwares and softwares. It is likely that the medical information processing is useful in clinics and pharmacy, pharmaceutical information processing is helpful in the more basic researches. The educational methodology of the medical and pharmceutical infomatics has not been established. It will be essential to systematize these educational methods. On the other hand, the thrapeutic drug monitoring (TDM) are carried out for a suitable and good drug usage and a Quality of life. The simulation programs for the concentration of drugs in blood are complicatted commonly. A general-purpose program of TDM simulation will be required for doctors, pharmacists and patients. In this study, we constract the database of the drug information and the facile TDM simulation program for the educational and clinical applications.1. The TDM simulation program was made by Microsoft Visual Basic. Three kinetic (linear 1-compartment, non-l … More inear 1-compartment and linear 2-compartments) models were shared. Phenobarbital, carbamazepine, valproate, phenytoin, lidocaine, and amikacin were constructed as model drugs. This progam was able to change some kinetic parameters freely and the drug concentration curves in blood drawed very easy, only by clicking one button. A part of the results was presented in the 118th anual meeting of the Pharmaceutical Society of Japan (Mar., 1998, Kyoto).2. Microsoft Access97 made the database of the preparation of lnfrrming sheets for the drug information for patients, that covered about 1200 drug informations, namely the usages, efficacies, harmful aftereffects and notes. This application may be useful for informing against patients by pharmacists. A part of the results was presented in the 119th anual meeting of the Pharmaceutical Society of Japan (Mar., 1999, Tokushima).3. The two application programs were used in the curriculum of our Faculty and highly regarded by the students. For the estimation and systematization of the medical and pharmaceutical informatics, the improvements of these programs and the developments of other tools are progressed. Less

近年来，计算环境在硬件和软件方面都得到了迅速发展。医学信息处理在临床和药学上有很大的应用前景，药学信息处理有助于更基础的研究。医药信息学教育方法论尚未建立。必须使这些教育方法系统化。另一方面，为了合理用药和提高生活质量，进行了治疗药物监测（TDM）。药物血药浓度的模拟程序一般比较复杂。一个通用的TDM模拟程序将需要医生，药剂师和病人。在本研究中，我们建立了药物信息数据库和简单的TDM模拟程序，用于教育和临床应用。用Microsoft Visual Basic编制了TDM仿真程序。三种动力学（线性单室，非线性） ...更多信息线性1-房室和线性2-房室）模型。以苯巴比妥、卡马西平、丙戊酸钠、苯妥英钠、利多卡因和阿米卡星为模型药物。该软件能够自由改变某些动力学参数，只需点击一个按钮即可绘制血药浓度曲线。部分结果在日本药学会第118届年会（3月，1998，京都）。Microsoft公司在1997年建立了病人用药信息说明书数据库，其中包括药品的用法、疗效、不良反应、注意事项等1200余项药品信息。此应用程序可能有助于药剂师向患者提供信息。部分结果在日本药学会第119届年会（3月，1999，德岛）。这两个应用程序被用于我们学院的课程，并受到学生的高度评价。为了对医药信息学进行评估和系统化，这些程序的改进和其他工具的开发也取得了进展。少