The Effect of Progressive Muscle Relaxation with Music for Nausea and Vomiting Related to Chemotherapy : in Concerning about Anxiety, Age, and Natural Killer Cell Activity

本研究旨在探讨渐进性肌肉放松（PMR）配合音乐治疗（M）的效果，恶心/呕吐/干呕（NVR）与年龄、焦虑的关系，NVR与各周期的关系，以及自然杀伤细胞活性（Nkact）、白色细胞、生长激素、受试者为M大学医院和两所综合医院的35名接受化疗的住院癌症患者（实验组：20名，对照组：15名）。平均年龄为54.3岁，结果显示了M-PMR的有效性趋势，但无统计学意义。实验组NVR评分为2.313分，对照组为3.466分。但在大学医院的患者有PMR与M的有效性（p<0.05）。大学医院患者的平均年龄比两家医院的患者小10岁。NVR与年龄的关系显示，年轻患者的NVR比老年患者的NVR高（r=-0.534）。因此，年龄越小的患者NVR越长，PMR的效果越好，NVR与焦虑的关系无统计学意义。而大学生的NVR越高，焦虑状态越强（r= 0.68）。周期1的NVR评分高于周期2和周期3。因此，护理人员应帮助患者在第1周期不发生严重的NVR，也不产生强烈的焦虑。Nkact，白色血细胞，生长激素等在使用PMR与M时的变化在此未显示，因为没有足够的数据进行分析。因此，这项研究一直在继续。

This study was to examine about 1) the effect of progressive muscle relaxation (PMR) with music therapy (M), 2) the relationships among nausea/vomiting/retching (NVR), age, and anxiety, 3) the relationship between NVR and each cycle, and 4) the change of natural killer cell activity (Nkact), white blood cell, growth hormone, and others in using PMR with M.Subjects are 35 hospitalized cancer patients having chemotherapy (experimental group : 20, control group : 15) at M University hospital and two general hospitals. The average age was 54.3 years old.The result showed the trend of the effectiveness of PMR with M, although it was not statistically significant. The scores of NVR were 2.313 for the experimental group and 3.466 for the control group. But the patients at the university hospital had the effectiveness of PMR with M (p<.05). The average age of the patients at the university hospital was 10 years younger than the patients at two hospitals. And the relationship between NVR and age showed that the younger patients had severer NVR than the older patients (r=-.534). Thus, the younger patients may have severer NVR and get more effect of PMR than the older patients.There was not statistically significance for the relationship between NVR and anxiety. But the patients at the university showed that the severer NVR was, the stronger anxiety (state) was (r=.68). And Cycle 1 showed more scores of NVR than cycle 2 and cycle 3. Thus, it is important for nurse to help the patients not to experience sever NVR at cycle 1 and also not to have strong anxiety.The change of Nkact, white blood cell, growth hormone, and others in using PMR with M has not been shown here because there were not enough data to analyze. Therefore, this study has been continuing.