Stimuli-responsive porphyrin-polymer systems for biomedical and sensing applications

本课题的目的是基于亲水生物相容性/可生物降解聚合物与光活性卟啉单元的连接，设计/合成光稳定刺激响应型卟啉-聚合物偶联物并进行理化表征。在FY2022，建立了合成方法。制备了多种卟啉与生物相容性聚乙二醇（PEG）和聚n -异丙基丙烯酰胺（PNIPAM）的偶联物。采用NMR， UV-Vis， FTIR， DSC， SEM和TEM进行了基本表征。对卟啉- pnipam偶联物的相分离性能进行了详细的研究。该体系在相分离温度32℃以下（即一维超分子聚合物）和以上（即大球状结构）表现出不同的结构。这些结构可以通过ph进一步调节。此外，通过对合适的聚合物进行热处理，制备了高多孔功能材料（表面积为> 3000m2 /g）。

The purpose of this project is the design/synthesis and physicochemical characterization of photostable stimuli-responsive porphyrin-polymer conjugates based on the connection of hydrophilic biocompatible/biodegradable polymer with photoactive porphyrin unit. In FY2022, synthetic methods were established. Various porphyrin conjugates with biocompatible polyethylene glycol (PEG) and poly(N-isopropylacrylamide) (PNIPAM) were prepared. Basic characterization using NMR, UV-Vis, FTIR, DSC, SEM and TEM were performed. Detailed investigation of phase-separation properties of porphyrin-PNIPAM conjugates was undertaken. The system exhibits different structures below phase separation temperature ca. 32°C (i.e. 1D supramolecular polymer) and above (i.e. large globular structures). These structures are further tunable by pH.Also, highly porous functional materials (with surface area >3000 m2/g) were prepared by thermal treatment of suitable polymers.