Stimuli-responsive porphyrin-polymer systems for biomedical and sensing applications

本项目的目的是基于亲水性、生物相容性/生物降解性聚合物与光活性卟啉单元的连接，设计、合成和表征光稳定的刺激响应型卟啉-聚合物偶联物。在2022财年，建立了合成方法。制备了生物相容的聚乙二醇聚N-异丙基丙烯酰胺(PNIPAM)与不同类型的卟啉偶联物。用核磁共振、紫外-可见光谱、红外光谱、差示扫描量热仪、扫描电子显微镜和透射电子显微镜对其进行了基本表征。详细研究了卟啉-PNIPAM偶联物的相分离性质。在相分离温度低于约32℃(即一维超分子聚合物)和高于32℃(即大球状结构)时，体系呈现出不同的结构。此外，通过对合适的聚合物进行热处理，制备了高孔功能材料(比表面积为&3000m2/g)。

The purpose of this project is the design/synthesis and physicochemical characterization of photostable stimuli-responsive porphyrin-polymer conjugates based on the connection of hydrophilic biocompatible/biodegradable polymer with photoactive porphyrin unit. In FY2022, synthetic methods were established. Various porphyrin conjugates with biocompatible polyethylene glycol (PEG) and poly(N-isopropylacrylamide) (PNIPAM) were prepared. Basic characterization using NMR, UV-Vis, FTIR, DSC, SEM and TEM were performed. Detailed investigation of phase-separation properties of porphyrin-PNIPAM conjugates was undertaken. The system exhibits different structures below phase separation temperature ca. 32°C (i.e. 1D supramolecular polymer) and above (i.e. large globular structures). These structures are further tunable by pH.Also, highly porous functional materials (with surface area >3000 m2/g) were prepared by thermal treatment of suitable polymers.