Stimuli-responsive porphyrin-polymer systems for biomedical and sensing applications

用于生物医学和传感应用的刺激响应卟啉聚合物系统

• 批准号: 22KF0385
• 负责人: Labuta Jan
• 金额: $ 1.47万
• 依托单位: National Institute for Materials Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for JSPS Fellows
• 财政年份: 2023
• 资助国家: 日本
• 起止时间: 2023-03-08 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22KF0385/
• 关键词: Polymers; Porphyrins; Phase separation; Sensing; Energy storage; Porosity

The purpose of this project is the design/synthesis and physicochemical characterization of photostable stimuli-responsive porphyrin-polymer conjugates based on the connection of hydrophilic biocompatible/biodegradable polymer with photoactive porphyrin unit. In FY2022, synthetic methods were established. Various porphyrin conjugates with biocompatible polyethylene glycol (PEG) and poly(N-isopropylacrylamide) (PNIPAM) were prepared. Basic characterization using NMR, UV-Vis, FTIR, DSC, SEM and TEM were performed. Detailed investigation of phase-separation properties of porphyrin-PNIPAM conjugates was undertaken. The system exhibits different structures below phase separation temperature ca. 32°C (i.e. 1D supramolecular polymer) and above (i.e. large globular structures). These structures are further tunable by pH.Also, highly porous functional materials (with surface area >3000 m2/g) were prepared by thermal treatment of suitable polymers.

该项目的目的是基于亲水性生物相容性/可生物降解聚合物与光活性卟啉单元的连接，设计/合成和物理化学表征光稳定刺激响应性卟啉-聚合物缀合物。 2022财年，建立了合成方法。制备了具有生物相容性聚乙二醇（PEG）和聚（N-异丙基丙烯酰胺）（PNIPAM）的各种卟啉缀合物。使用 NMR、UV-Vis、FTIR、DSC、SEM 和 TEM 进行基本表征。对卟啉-PNIPAM 缀合物的相分离特性进行了详细研究。该系统在相分离温度以下表现出不同的结构。 32°C（即一维超分子聚合物）及以上（即大球状结构）。这些结构可通过 pH 进行进一步调节。此外，通过对合适的聚合物进行热处理，制备了高度多孔的功能材料（表面积 >3000 m2/g）。

项目成果

Physicochemical Analysis of Star-Shaped Porphyrin-PNIPAM4 Conjugates: Phase-Separation and pH-Dependent Phenomena

星形卟啉-PNIPAM4 缀合物的物理化学分析：相分离和 pH 依赖性现象

• 发表时间: 2022
• 作者: Nadiia Velychkivska;Jan Labuta
• 通讯作者: Jan Labuta

Phase Separation and pH-Dependent Behavior of Four-Arm Star-Shaped Porphyrin-PNIPAM4 Conjugates

四臂星形卟啉-PNIPAM4 缀合物的相分离和 pH 依赖性行为

• DOI: 10.1021/acs.macromol.1c02188
• 发表时间: 2022
• 期刊: Macromolecules
• 影响因子: 5.5
• 作者: Velychkivska Nadiia;Sedlacek Ondrej;Shatan Anastasiia B.;Spasovova Monika;Filippov Sergey K.;Chahal Mandeep K.;Janisova Larisa;Brus Jiri;Hanykova Lenka;Hill Jonathan P.;Winnik Francoise M.;Labuta Jan
• 通讯作者: Labuta Jan

Phase-Separable and pH-Sensitive Star-Shaped Porphyrin-PNIPAM Conjugates

相分离且 pH 敏感的星形卟啉-PNIPAM 缀合物

• 发表时间: 2022
• 作者: Jan Labuta;Nadiia Velychkivska
• 通讯作者: Nadiia Velychkivska

Phase Separation and pH-dependent Behavior of Star-Shaped Porphyrin-PNIPAM4 Conjugates

星形卟啉-PNIPAM4 缀合物的相分离和 pH 依赖性行为

• 发表时间: 2022
• 作者: Jan Labuta;Nadiia Velychkivska
• 通讯作者: Nadiia Velychkivska