Calcium metabolism in normal pregnancy and pregnancy induced hypertension

正常妊娠和妊娠高血压综合征的钙代谢

• 批准号: 09671698
• 负责人: ITO Masaharu
• 金额: $ 1.79万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671698/
• 关键词: pregnancy induced hypertension; uterine artery; calcium; calcium; orotic acid; pregnanoy induced hypertension; wterine artery; preload index; pregnancy induced hypertension; calcium ion; uterine artery; pregnancy mduced hypertension; Doppler /

Because pregnancy induced hypertension improves rapidly after delivery, it is thought to be caused by a disturbance in uteroplacental circulation. Injury to endothelial cells caused by serum may have a role in the onset of pregnancy induced hypertension. We investigated the relation between serum samples from women with pregnancy induced hypertension and endothelial cell Cas^<++>. The Ca^<++> was induced by serum samples from women with pregnancy induced hypertension. We believe that some factors in serum samples from women with pregnancy induced hypertension could modulate periodic secretion of nitric oxide by endothelial cells. Then, we investigated the basic biological significance of diastolic notches in uterine artery flow velocity waveforms. Five pregnant ewe at 16-17 weeks of pregnancy were used in the study. Micro-beads (Gelfoam) were stepwisely administered into the uterine artery and changes in uterine circulation were assessed by Doppler velocimetry. Pulsatility index linear … More ly correlated with uterine vascular resistance, giving a high correlation coefficient. The mean values of uterine vascular resistance and PI when diastolic notches appeared were 2.13±and 450±92 mmHg・min・L^<-1>, respectively. It could be concluded that the elevation of PI and presence of diastolic notches in the uterine arteries are indicators of high uterine vascular resistance and impaired uterine circulation. Furthermore, we investigated the urinary levels of orotic acid in normal pregnancy and in pregnancy-induced hypertension. Such levels were measured using high-performance liquid chromatography with column-switching. Normal pregnant individually showed a significant elevation at 20 and 30 weeks of gestation as compared with those in the first trimester. A high consumption of arginine in nitric oxide production during normal pregnancy may cause a physiological elevation of urinary orotic acid. The absence of an elevation in pregnancy-induced hypertension may be associated with a decrease in nitric oxide production. Less

由于妊娠高血压综合征在分娩后迅速改善，因此认为是由子宫胎盘循环障碍引起的。血清引起的内皮细胞损伤可能在妊娠高血压综合征的发病中起作用。本研究探讨了妊高征患者血清中内皮细胞Cas^<++>水平的关系。用妊娠高血压综合征患者血清诱发Ca^<++>。我们认为，从妊高征妇女血清样品中的某些因素可以调节内皮细胞周期性分泌一氧化氮。然后，我们探讨了子宫动脉血流速度波形舒张期切迹的基本生物学意义。研究中使用了5只妊娠16-17周的妊娠母羊。微珠（Gelfoam）逐步管理到子宫动脉和子宫循环的变化进行了评估多普勒测速。脉动指数线性 ...更多信息 ly与子宫血管阻力相关，相关系数高。舒张期切迹出现时子宫血管阻力和PI的平均值分别为2.13± 2.13和450±92 mmHg·min·L^<-1>。可以得出结论，子宫动脉PI升高和舒张期切迹的存在是子宫血管阻力高和子宫循环受损的指标。此外，我们调查了正常妊娠和妊娠高血压综合征患者的尿乳清酸水平。使用具有柱切换的高效液相色谱法测量这些水平。正常妊娠个体在孕20、30周较孕早期明显升高。在正常妊娠过程中，一氧化氮生成过程中精氨酸的大量消耗可能导致尿乳清酸的生理性升高。妊娠高血压不升高可能与一氧化氮产生减少有关。少

项目成果

Ochi H,Matsubara K,Kusanagi Y Furutani K,Katayama T,Ito M: "Fetal compromise assessed by Doppler ultrasound of venous flow in pregnancy-induced hypertension."Gynecol Obstet Invest. 47. 235-8 (1999)

Ochi H、Matsubara K、Kusanagi Y Furutani K、Katayama T、Ito M：“通过多普勒超声评估妊娠高血压综合征中的静脉血流来评估胎儿受损情况。”Gynecol Obstet Invest。

Ochi H, Matsubara K, Kusanagi Y, Furutani K, Katayama T, Ito M: "The influence of the maternal heart rate on the uterine artery pulsatility index in the pregnant ewe."Gynecol Obstet Invest. 47. 73-5 (1999)

Ochi H、Matsubara K、Kusanagi Y、Furutani K、Katayama T、Ito M：“母亲心率对怀孕母羊子宫动脉搏动指数的影响。”Gynecol Obstet Invest。

Ochi H., Matsubara K, Kusanagi,Y. Furutani K, Katayama T, Ito M.: "The Influence of the Maternal Heart Rate on the uterine Artery Pulsatility Index in the Pregnant Ewe" Gynecologic Obstetric Investigation. 47. 73-75 (1999)

Ochi H.、松原 K、草薙 Y.

Ochi H,Matsubara K,Kusanagi Y,Furutani K,Katayama T,Ito M: "The Influence of the maternal Heart Rate on the Uterine Artery Polsatility Index in the Pregnant Ewe"Gynecologic Ostetric Investigation. 47. 73-75 (1999)

Ochi H，Matsubara K，Kusanagi Y，Furutani K，Katayama T，Ito M：“孕妇心率对怀孕母羊子宫动脉波度指数的影响”妇科骨科调查。

Matsubara,K., Ochi,H., Kitagawa,H., Ito.M., Oka K.: "Ca^<++> oscillation in endothelial cells and pre-eclampsia." THE LANCET. 351. 1490-1491 (1998)

Matsubara,K.、Ochi,H.、Kitakawa,H.、Ito.M.、Oka K.：“内皮细胞中的 Ca^< > 振荡和先兆子痫。”