Molecular Immunology study of t

我们正在鉴定和鉴定能够诱导自身免疫性疾病的抗原。眼内存在大量器官特异性抗原。大多数在视网膜中特异性表达的蛋白质具有诱导自身免疫性葡萄膜视网膜炎的潜力。这些事实表明，该蛋白表达的量和时间可能与自身免疫耐受有关。为了了解更多关于抗原呈递和自身反应性T细胞之间的关系，我们现在正在制造只在视网膜中表达促突触素的大鼠。这些大鼠可以通过使缺乏突触营养素的大鼠与在视网膜中表达突触营养素的转基因大鼠交配来获得。我们现在正在让这些老鼠交配，但还没有让老鼠只在视网膜中表达syntrophine，我们现在正在制造另一个使用酪氨酸酶的实验系统。酪氨酸酶在白化病动物中缺乏，这些动物作为酪氨酸酶敲除动物工作。在不同启动子下表达酪氨酸酶的转基因大鼠可能对我们的目的有用。这些大鼠被获得并交配用于实验。

We are identifying and characterizing the antigens that are able to induce an autoimmune disease. There are a lot of organ specific antigens in the eye. Most of the proteins expressed specifically in the retina have the potential to induce autoimmune uveo-retinitis. These facts showed that the amount and period of the expression of the protein may related to the tolerance of autoimmunity. To learn more about these relations between antigen presentation and auto-reactive T cells, We are now making the rats that express syntrophine only in the retina. These rats may be obtained by mating the rats lacking syntrophine and transgenic rats expressing syntrophine in the retina. We are now mating these rats, but not yet have the rats expressing syntrophine only in the retina.We are now making another experimental system using tyrosinase also. Tyrosinase is lacking in albino animals and these animals work as the tyrosinase knock out animals. The transgenic rats express the tyrosinase under the various promoters may be useful for our purpose. These rats were obtained and now mated for experiments.