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Neuronal connection in the LGN and the function of the centrifugal optic nerve fiber

LGN 中的神经元连接和离心视神经纤维的功能

基本信息

批准号：
09671814
负责人：
NIIDA Takahiro
金额：
$ 1.79万
依托单位：
Kitasato University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 2000
项目状态：
已结题

项目摘要

The responses properties of corticotectal (CT) and corticostriatal (CS) neurons in the posterior lateral suprasylvian cortex (LS) of the cat were examined. While CT and CS neurons in LS share many of the same response properties, there are, apparently, differences such as velocity tuning, receptive field size and direction selectivity. Such differences are consistent with the anatonical segregation of these two pathways.Furthermore, to elucidate the influence of auditory selective attention upon the visual system, simultaneous recordiuags of pattern electroretinogram (PERG) and pattern visual evoked cortical potential (PVECP) were conducted when auditory task was give nor not. Selective auditory attention resulted in the reduction of both P1 auad N2 amplitudes of PERG.Using same procedure, tonic interocular suppression (TIS) was analyzed during dark adaptation or after light adaptation of the other eye. During dark adaptation, amplitudes of PERG and PVECP were decreased transiently. In contrast, amplitudes of PERG and PVECP were increased transiently after the light adaptation. These results suggest that in human, neuronal mechanizm of auditory selective attention as well as of TIS is, at least in part, attributable to retinal origin since PERG mainly reflects the retinal activities includung the retinal ganglion cells. Postulated centrifugal optic nerve fiber may be involved in this mechanizm.

检查了猫外侧外侧上皮质 (LS) 的皮质顶盖 (CT) 和皮质纹状体 (CS) 神经元的反应特性。虽然 LS 中的 CT 和 CS 神经元具有许多相同的响应特性，但显然存在速度调谐、感受野大小和方向选择性等差异。这种差异与这两条通路的解剖分离一致。此外，为了阐明听觉选择性注意对视觉系统的影响，在给予或不给予听觉任务时同时记录模式视网膜电图（PERG）和模式视觉诱发皮层电位（PVECP）。选择性听觉注意导致 PERG 的 P1 和 N2 振幅降低。使用相同的程序，在另一只眼睛的暗适应期间或光适应之后分析紧张性眼间抑制 (TIS)。在暗适应过程中，PERG 和 PVECP 的幅度短暂下降。相反，PERG 和 PVECP 的振幅在光适应后短暂增加。这些结果表明，在人类中，听觉选择性注意以及 TIS 的神经元机制至少部分归因于视网膜起源，因为 PERG 主要反映包括视网膜神经节细胞在内的视网膜活动。假定的离心视神经纤维可能参与这种机制。