GRK 1166: Ionic Liquids, Organic Solvents, Supercritical Fluids and Gases as Reaction Media for Bio-catalysed Syntheses

GRK 1166：离子液体、有机溶剂、超临界流体和气体作为生物催化合成的反应介质

• 批准号: 811503
• 金额: --
• 依托单位: Heinrich-Heine-Universität Düsseldorf
• 依托单位国家: 德国
• 项目类别: Research Training Groups
• 财政年份: 2005
• 资助国家: 德国
• 起止时间: 2004-12-31 至 2013-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/811503?language=en
• 关键词: GRK; 1166; Ionic; Liquids; Organic

The Research Training Group promotes the specialisation of PhD-students and young scientists in biocatalysis, a scientific area covering biology, chemistry and biochemical engineering. Due to selectivity and flexibility, biocatalysis is gaining more and more importance in the sustainable provision of building blocks for pharmaceutical compounds and fine chemicals. The combination of biocatalysts with non-conventional, i.e. not mainly aqueous, media offers a specially high potential for development.

研究培训小组促进博士生和年轻科学家在生物催化方面的专业化，这是一个涵盖生物学，化学和生物化学工程的科学领域。由于选择性和灵活性，生物催化在可持续地提供药物化合物和精细化学品的结构单元方面越来越重要。生物催化剂与非常规介质（即主要不是水性介质）的组合提供了特别高的开发潜力。

项目成果

Redirecting catalysis from proteolysis to perhydrolysis in subtilisin Carlsberg.

• DOI: 10.1016/j.jbiotec.2013.06.017
• 发表时间: 2013-09
• 期刊: Journal of biotechnology
• 影响因子: 4.1
• 作者: Dragana Despotović;Ljubica Vojcic;M. Blanusa;K. Maurer;M. Zacharias;M. Bocola;Ronny Martínez;U. Schwaneberg

Facile biocatalytic synthesis of a macrocyclic lactone in sub- and supercritical solvents

在亚临界和超临界溶剂中轻松生物催化合成大环内酯

• DOI: 10.3109/10242422.2014.893579
• 发表时间: 2014
• 期刊: Biocatalysis and Biotransformation
• 影响因子: 1.8
• 作者: Karmee SK;Niemeijer B;Casiraghi L;Mlambo B;Lapkin A;Greiner L
• 通讯作者: Greiner L

Stability, activity, and selectivity of benzaldehyde lyase in supercritical fluids

超临界流体中苯甲醛裂解酶的稳定性、活性和选择性

• DOI: 10.1016/j.supflu.2011.11.025
• 发表时间: 2012
• 期刊: Journal of Supercritical Fluids
• 影响因子: 3.9
• 作者: Natalia D;Greiner L;Leitner W;Ansorge-Schumacher MB
• 通讯作者: Ansorge-Schumacher MB

Assessing biocatalysis for the synthesis of optically active tetrahydropyrazolo[1,5-α]pyrimidines (THPPs) as novel therapeutic agents

• DOI: 10.1016/j.molcatb.2013.11.012
• 发表时间: 2014-02-01
• 期刊: JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
• 作者: Fernandez-Alvaro, Elena;Esquivias, Jorge;Remuinan-Blanco, Modesto J.
• 通讯作者: Remuinan-Blanco, Modesto J.

Directed laccase evolution for improved ionic liquid resistance

• DOI: 10.1039/c3gc36899h
• 发表时间: 2013-01-01
• 期刊: GREEN CHEMISTRY
• 影响因子: 9.8
• 作者: Liu, Haifeng;Zhu, Leilei;Schwaneberg, Ulrich
• 通讯作者: Schwaneberg, Ulrich