A study on the biological features of age-associated memory impairment (AAMI).

为了阐明年龄相关性记忆损害的生物学特征，我们对正常对照组老年人、老年记忆损害患者、早发型阿尔茨海默型痴呆(AD)和晚发型阿尔茨海默型痴呆(AD)和血管性痴呆(VD)患者进行了托吡卡胺稀释滴眼试验、血清载脂蛋白E epsilon 4等位基因(αE epsilon 4，α4)和血清Apo1-ACT浓度的测定。采用严格的纳入与排除标准(NINCDS-ADRDA)，纳入AD患者18例(63.1±5.8岁)，SDAT患者26例(77.2±4.7岁)，VD患者27例(75.0±6.7岁)。对于急性心肌梗死和非痴呆对照(C)，24(64.3±12.2y.O.)21例(67.6±9.3)结果与结论：1)对0.01%托吡卡胺的反应，AAMI组(8.6±6.2%)与C组(7.8±5.5%)相近，与AD组(23.3±19.1%)和SDAT组(22.0±14.5%)差异有统计学意义(p&lt；0.1)。血清α-1-ACT值分别为278.10±36.3g/ml、259.6±32.7g/ml、303.7±87.8g/m l、324.2±82.6g/m l、314.7±72.5g/m l，与正常对照组比较差异有统计学意义(p&lt；P<0.05)。3)ε-4等位基因频率以心绞痛组最高(40.0±40.8%)，AAMI值(2 0.8±2 9.2%)介于C组(12.5±2 7.5%)和AD组(31.3±40.3%)之间。我们的结果提示，急性心肌梗死可能不是一个独立的临床实体，而是一个由多种群体组成的实体，如完全正常的老年人和非常早期的阿尔茨海默型痴呆。

In order to clarify the biological features of age-associated memory impairment(AAMI) we investigated dilute tropicamide eye drop tests, serum α 1-antichimotrypsine (α 1-ACT) concentrations and apolipoprotein E epsilon 4 allele (ApoE4) frequencies in the normal control elderlys, AAMI subjects, the patients with Alzheimer type dementia(ATD) of early onset type(Alzheimer's disease : AD) and late onset type(senile dementia of Alzheimer's type : SDAT), and those with vascular dementia(VD). Using strict inclusion and exclusion criteria (NINCDS-ADRDA), we recruited 18 patients of AD (63.1±5.8 years old), 26 of SDAT(77.2±4.7 y.o.), 27 of VD(75.0±6.7 y,o.). Regarding AAMI and non-demented controls (C), 24(64.3±12.2 y.o.) and 21(67.6±9.3 y.o.) of persons were enrolled, respectively.Results and conclusion :1) In response to the administration of 0.01% of tropicamide, the value of AAMI group(8.6±6.2%) was nearly equal to that of C group(7.8±5.5%), which tended to be significant to AD-(23.3±19.1%) and SDAT groups(22.0±14.5%)(p<0.1). However, there was no significant differences to either AD or SDAT group.2) Serum α1-ACT values were 278.10±36.3(μg/ml) in AAMI, 259.6±32.7 in C, 303.7±87.8 in AD, 324.2±82.6 in SDAT, 314.7±72.5 in VD group, respectively, so that there was a significant difference only between SDAT and C group (p<0.05).3) The ε4 allele frequency showed the highest value in SDAT group(40.0±40.8%), and the value of AAMI(20.8±29.2%) was beween C(12.5±27.5%) and AD(31.3±40.3%). However, there was no significant difference among each group.Our results suggest that AAMI might not be a distinct clinical entity, but the one which consists of a variety of group such as entirely normal eldelys and a very early stage of Alzheimer Type Dementia.