The role of tenascin family molecules in brain tumors

我们研究tenascin- c （TN-C）、tenascin- r （TN-R）和tenascin- x （TN-X）在人脑胶质瘤中的表达，以阐明tenascin家族分子在脑肿瘤中的功能。TN-X的分布通常与TN-C的分布成反比。培养的胶质母细胞瘤细胞表达一种胶质瘤-间充质细胞外基质糖蛋白，与TN-C相同，其表达程度与人类胶质瘤的肿瘤分级有关。在高级别胶质瘤中，TN-C在细胞间隙和肿瘤血管中表达更为强烈。相比之下，TN-X主要局限于肿瘤血管周围的血管周间质。虽然间变性星形细胞瘤（III级）的细胞间隙中TN-R的表达高于成胶质细胞瘤（IV级），但原位杂交表明，TN-C由胶质瘤细胞和内皮细胞产生，而TN-R仅由胶质瘤细胞产生。因此，TN-C可能在胶质瘤细胞的迁移、增殖和新生血管形成中起重要作用。n - x可能在新生血管形成中起不同作用，TN-C可能在胶质瘤细胞增殖中起不同作用。

We studied the expression of tenascin-C (TN-C), tenascin-R (TN-R), and tenascin-X (TN-X) in human gliomas to clarify the functions of tenascin family molecules in brain tumors. The distribution of TN-X was often reciprocal to that of TN-C.Cultured glioblastoma cells express a glioma-mesenchymal extracellular matrix glycoproteins, shown to be identical to TN-C, the degree of expression being linked to tumor grade in human gliomas. TN-C was more strongly expressed in the intercellular spaces and in tumor vessels in high-grade gliomas. In contrast, TN-X was mainly localized in the perivascular stroma around tumor vessels. While TN-R expression in the intercellular spaces is greater in anaplastic astrocytomas (Grade III) than inglioblastomas (Grade IV), In situ hybridization demonstrated that TN-C was produced by glioma cells and endothelial cells, and TN-R was produced only by glioma cells. Therefore TN-C may play significant roles inmigration and proliferation of glioma cells, and neovascularization. TN-X may play different roles in neovascularization, TN-C may in proliferation of glioma cells.