Vascular endothelial growth factor (Vascular permeability factor) and its receptor expression in outer membrane of chronic subdural hematomas

慢性硬膜下血肿外膜血管内皮生长因子（血管通透因子）及其受体表达

• 批准号: 09671446
• 负责人: SUGIYAMA Satoru
• 金额: $ 1.47万
• 依托单位: Saitama Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671446/
• 关键词: Chronic Subdural Hematoma; Outer Membrane; Expression of VEGF (VPF); Increase of Hematoma; Sinusoid; 血種増大; VEGF; VPF; 血腫形成

Chronic subdural hematoma is one of the most common diseases in neurosurgery. And there have been numerous clinical and experimental studies concerning the etiology, the mechanisms of their development, especially their increase in size of chronic subdural hematomas, have remained controversial.In order to study the mechanisms of increase in size of chronic subdural hematomas, we observed HE stained and immunohistochemically stained vascular endothelial growth factor (VEGF) and its receptor in outer membranes of chronic subdural hematoma. VEGF is a factor for angiogenesis and vascular permeability resulting from endothelial cell proliferation. The outer membrane of chronic subdural hematomas was composed of infiltrating cells such as fibroblasts, endothelial cells, lymphocytes, and eosinocytes. VEGF was expressed in the endothelial cells and infiltrating cells, and its receptor was also seen in the endothelial cells and their adjacent infiltrating cells.So it is suggested that VEGF is one of the most important factor for the mechanism of the increase in size of chronic subdural hematomas.

慢性硬膜下血肿是神经外科最常见的疾病之一。为了探讨慢性硬膜下血肿扩大的机制，我们采用HE染色和免疫组化染色方法，观察了慢性硬膜下血肿外膜血管内皮生长因子（VEGF）及其受体的表达。VEGF是由内皮细胞增殖引起的血管生成和血管通透性的因子。慢性硬膜下血肿的外膜由浸润细胞如成纤维细胞、内皮细胞、淋巴细胞和嗜酸性细胞组成。VEGF在血管内皮细胞和浸润细胞中均有表达，其受体在血管内皮细胞及其邻近的浸润细胞中也有表达，提示VEGF是慢性硬膜下血肿体积增大的重要机制之一。

项目成果

Satoru Sugiyama: "Vascular Endothelial Growth Factor (Vascular Permeability Factor) and its Receptors Expression in Outer Membrane of Chronic Subdural Hematomas"Japanese Journal of Neurosurgery. (in Press).

杉山悟：“血管内皮生长因子（血管通透性因子）及其受体在慢性硬膜下血肿外膜中的表达”日本神经外科杂志。

杉山聡 他: "慢性硬膜下血腫外膜における血管内皮細胞増殖因子(血管透過性因子)の発現"脳神経外科ジャーナル. (in press).

Satoshi Sugiyama 等人：“慢性硬膜下血肿外膜中血管内皮生长因子（血管通透性因子）的表达”神经外科杂志（正在出版）。