Vascular endothelial growth factor (Vascular permeability factor) and its receptor expression in outer membrane of chronic subdural hematomas

慢性硬膜下血肿是神经外科最常见的疾病之一。对于慢性硬膜下血肿的发病机制，尤其是其体积的增大，已有大量的临床和实验研究，但仍存在争议。为了研究慢性硬膜下血肿体积增大的机制，我们对慢性硬膜下血肿外膜血管内皮生长因子及其受体进行了HE染色和免疫组织化学染色。血管内皮生长因子是由内皮细胞增殖引起的血管生成和血管通透性的因子。慢性硬膜下血肿的外膜由成纤维细胞、内皮细胞、淋巴细胞和嗜酸性粒细胞等浸润性细胞组成。血管内皮生长因子表达于内皮细胞和浸润性细胞，其受体也表达于内皮细胞和邻近的浸润性细胞，提示血管内皮生长因子是慢性硬膜下血肿体积增大的重要机制之一。

Chronic subdural hematoma is one of the most common diseases in neurosurgery. And there have been numerous clinical and experimental studies concerning the etiology, the mechanisms of their development, especially their increase in size of chronic subdural hematomas, have remained controversial.In order to study the mechanisms of increase in size of chronic subdural hematomas, we observed HE stained and immunohistochemically stained vascular endothelial growth factor (VEGF) and its receptor in outer membranes of chronic subdural hematoma. VEGF is a factor for angiogenesis and vascular permeability resulting from endothelial cell proliferation. The outer membrane of chronic subdural hematomas was composed of infiltrating cells such as fibroblasts, endothelial cells, lymphocytes, and eosinocytes. VEGF was expressed in the endothelial cells and infiltrating cells, and its receptor was also seen in the endothelial cells and their adjacent infiltrating cells.So it is suggested that VEGF is one of the most important factor for the mechanism of the increase in size of chronic subdural hematomas.