GRK 1208: Hormonal Regulation of Energy Metabolism, Body Weight and Growth

GRK 1208：能量代谢、体重和生长的激素调节

• 批准号: 823482
• 金额: --
• 依托单位: Freie Universität Berlin
• 依托单位国家: 德国
• 项目类别: Research Training Groups
• 财政年份: 2005
• 资助国家: 德国
• 起止时间: 2004-12-31 至 2013-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/823482?language=en
• 关键词: GRK; 1208; Hormonal; Regulation; Energy

Hormones and endocrine feedback circuits are key regulators of development, differentiation, growth, and maintenance of an intact organism, and of processes related to aging and adaptation to disease or altered environment. The Research Training Group will address in an interdisciplinary, multi-institutional approach several hormone systems involved in these processes in higher mammalian organisms, including man.

激素和内分泌反馈回路是发育、分化、生长和维持完整生物体，以及与衰老和适应疾病或环境变化有关的过程的关键调节因素。研究培训小组将以跨学科、多机构的方法研究包括人类在内的高等哺乳动物生物中参与这些过程的几种激素系统。

项目成果

Impaired selenoprotein expression in brain triggers striatal neuronal loss leading to co-ordination defects in mice.

脑中硒蛋白的表达受损会触发纹状体神经元丧失，从而导致小鼠的协同缺陷。

• DOI: 10.1042/bj20140423
• 发表时间: 2014-08-15
• 期刊: The Biochemical journal
• 作者: Seeher S;Carlson BA;Miniard AC;Wirth EK;Mahdi Y;Hatfield DL;Driscoll DM;Schweizer U
• 通讯作者: Schweizer U

The ARF-Like GTPase ARFRP1 Is Essential for Lipid Droplet Growth and Is Involved in the Regulation of Lipolysis

• DOI: 10.1128/mcb.01269-09
• 发表时间: 2010-03-01
• 期刊: MOLECULAR AND CELLULAR BIOLOGY
• 影响因子: 5.3
• 作者: Hommel, Angela;Hesse, Deike;Schuermann, Annette
• 通讯作者: Schuermann, Annette

Identification of the Translation Start Site of the Human Melanocortin 3 Receptor

• DOI: 10.1159/000336070
• 发表时间: 2012-03-01
• 期刊: OBESITY FACTS
• 影响因子: 3.6
• 作者: Tarnow, Patrick;Rediger, Anne;Biebermann, Heike
• 通讯作者: Biebermann, Heike

The role of human growth hormone's C-terminal disulfide bridge.

人生长激素C端二硫桥的作用

• DOI: 10.1016/j.ghir.2013.02.002
• 发表时间: 2013
• 期刊: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
• 作者: Junnila RK;Strasburger CJ
• 通讯作者: Strasburger CJ

A Heterozygous Mutation in the Third Transmembrane Domain Causes a Dominant-Negative Effect on Signalling Capability of the MC4R

第三跨膜结构域的杂合突变对 MC4R 信号传导能力产生显性负效应

• DOI: 10.1159/000138251
• 发表时间: 2008
• 期刊: Obesity Facts
• 影响因子: 3.6
• 作者: Tarnow P;Rediger A;Brumm H;Ambrugger P;Rettenbacher E;Widhalm K;Hinney A;Kleinau G;Schaefer M;Hebebrand J;Krause G;Grüters A;Biebermann H
• 通讯作者: Biebermann H