Basic research on "Pericardial pumping" as a circulatory assist device

“心包泵送”循环辅助装置的基础研究

• 批准号: 09670734
• 负责人: MORIKAWA Junichiro
• 金额: $ 0.96万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670734/
• 关键词: circulatory assist device; assister cup; sphygmomanometer cuff; volume respirator; left ventricular pressure; aortic flow volume; 心マッサージ法; 経食道心エコー; 前後方向圧迫; 左右方向圧迫; 僧帽弁逆流; 心外膜腔補助循環法; マンシェット; 超音波血流計

Background. The lack of a simple and safely applicable surgical strategy for refractory heart failure, designed to apply forces directly to the ventricular walls, led us to revise the assister cup proposed in the 1960's and develop a system consisting of a sphygmomanorneter cuff wrapped around the heart.Methods. A cuff measuring 3 cm wide was wrapped around both ventricles in twelve rabbits and pneumatically inflated and deflated cyclically during induced ventricular fibrillation using a volume respirator as the power unit.Results. Mean peak left ventricular pressure increased from 62.1*23.5 mmHg at the control to 75.5*20.0 mmHg during cuff assistance (p=0.054). Mean peak aortic flow volume decreased from 401.7*258.7 ml/min to 303.6*155.2 ml/min (p=0.070). Mean stroke volume, however, increased from 0.38*0.26 ml to 0.52*0.20 ml (p=0.025). Post-mortem study did not show any ecchymosis or bleeding.Conclusions. Advantages in cuff assistance include simplicity without vessel cannulation or contact with blood and superior fitting due to the flexibility of the material. Moreover, it has potential as a bridge to myocardial recovery.

背景缺乏一个简单和安全适用的手术策略，难治性心力衰竭，旨在直接施加力到心室壁，导致我们修改了辅助杯提出在20世纪60年代，并开发了一个系统，包括一个血压计袖带包裹在心脏。将宽3cm的袖带缠绕在12只家兔的两个心室周围，以容量呼吸器为动力，在诱发室颤时循环充气和放气。平均峰值左心室压力从对照组的62.1*23.5 mmHg增加至袖带辅助期间的75.5*20.0 mmHg（p=0.054）。平均峰值主动脉血流量从401.7*258.7 ml/min降至303.6*155.2 ml/min（p=0.070）。然而，平均每搏输出量从0.38*0.26 ml增加至0.52*0.20 ml（p=0.025）。尸检未发现任何瘀斑或出血。袖带辅助的优点包括简单，无需血管插管或与血液接触，以及由于材料的柔性而具有的上级贴合性。此外，它有潜力作为心肌恢复的桥梁。

项目成果

Morikawa J, Nishio M, Yamamoto T, and Kashima K: "Massive mitral regurgitation by laterally inward cardiac massage on transesophageal Doppler echocardiography" J Kyoto Pref Univ Med. (in press).

Morikawa J、Nishio M、Yamamoto T 和 Kashima K：“经食管多普勒超声心动图上横向向内心脏按摩导致的大量二尖瓣反流”J 京都府大学医学。

Morikawa J,et al.: "Massive mitral regurgitation by laterally inward cardiac massage on transesophageal Doppler echocardiography" J Kyoto Pref Univ Med. in press.

Morikawa J 等人：“经食管多普勒超声心动图横向向内心脏按摩导致二尖瓣反流”，京都府立大学医学杂志。

Morikawa J, et al.: "Massive mitral regurgitation by laterally inward cardiac massage on transesophageal Doppler echocardiography" J Kyoto Pret Univ Med. (in press).

Morikawa J 等人：“经食管多普勒超声心动图横向向内心脏按摩导致二尖瓣大量反流”J 京都 Pret Univ Med。