Basic research on "Pericardial pumping" as a circulatory assist device

背景资料。由于对难治性心力衰竭缺乏一种简单、安全适用的手术策略，即直接对室壁施力，我们对S在1960年提出的辅助杯进行了修改，并开发了一种由血压计袖带包裹心脏的系统。在12只兔的双侧脑室周围包裹3 cm宽的袖带，以容量呼吸器为动力单元，在诱发室颤的过程中循环充气和放气。平均左心室峰压从对照组的62.1x23.5mmHg升至袖带辅助时的75.5x20.0mmHg.(p=0.054)。平均峰值动脉血流量由401.7×258.7毫升/分降至303.6×155.2毫升/分(p=0.070)。平均每搏输出量从0.38x0.26ml增加到0.52x0.20ml(p=0.025)。尸检未见瘀斑或出血。袖带辅助的优点包括简单，不需要血管插管或与血液接触，以及由于材料的灵活性而具有更好的适配性。此外，它有可能成为心肌恢复的桥梁。

Background. The lack of a simple and safely applicable surgical strategy for refractory heart failure, designed to apply forces directly to the ventricular walls, led us to revise the assister cup proposed in the 1960's and develop a system consisting of a sphygmomanorneter cuff wrapped around the heart.Methods. A cuff measuring 3 cm wide was wrapped around both ventricles in twelve rabbits and pneumatically inflated and deflated cyclically during induced ventricular fibrillation using a volume respirator as the power unit.Results. Mean peak left ventricular pressure increased from 62.1*23.5 mmHg at the control to 75.5*20.0 mmHg during cuff assistance (p=0.054). Mean peak aortic flow volume decreased from 401.7*258.7 ml/min to 303.6*155.2 ml/min (p=0.070). Mean stroke volume, however, increased from 0.38*0.26 ml to 0.52*0.20 ml (p=0.025). Post-mortem study did not show any ecchymosis or bleeding.Conclusions. Advantages in cuff assistance include simplicity without vessel cannulation or contact with blood and superior fitting due to the flexibility of the material. Moreover, it has potential as a bridge to myocardial recovery.