The influence of murine Bactericidal/Permeability - Increasing protein on the function of dendritic cells

小鼠杀菌/通透性增加蛋白对树突状细胞功能的影响

• 批准号: 85583465
• 负责人: Professor Dr. Markus Schnare
• 金额: --
• 依托单位: Institut für Immunologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2013-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/85583465?language=en
• 关键词: influence; murine; Bactericidal; Permeability; Increasing

Antimicrobial proteins are important effector molecules of the innate immune response. Following pathogen encounter, polymorphonuclear granulocytes as well as epithelial cells at various anatomical sites secrete a broad spectrum of these proteins as a first line of host immune defense. The release and/or transcription of many antimicrobial proteins are controlled by Toll-like receptors (TLRs) that recognize pathogens based on their invariant structures. We have recently identified the mouse homologue of the human antimicrobial protein “bactericidal / permeability-increasing protein (BPI)”. The expression of this protein is mainly regulated by TLR4; however, the precise mechanism of its control has not yet been elucidated. In addition to neutrophils, mouse BPI is expressed by dendritic cells (DCs), where it remains retained intracellularly. The goal of this research is to analyze the function of BPI within DCs. This knowledge will further our understanding how DCs control phagocytozed pathogens and present antigen in order to promote the adaptive immune response.

抗菌蛋白是先天免疫应答的重要效应分子。在病原体遭遇后，多形粒细胞以及各种解剖部位的上皮细胞分泌广谱的这些蛋白质作为宿主免疫防御的第一道防线。许多抗微生物蛋白的释放和/或转录由Toll样受体（TLR）控制，Toll样受体基于其不变结构识别病原体。我们最近已经确定了人类抗菌蛋白“杀菌/渗透性增加蛋白（BPI）”的小鼠同源物。该蛋白的表达主要受TLR 4调控，然而，其调控的精确机制尚未阐明。除了嗜中性粒细胞，小鼠BPI由树突状细胞（DC）表达，其中其保持保留在细胞内。本研究的目的是分析BPI在DC中的功能。这些知识将有助于我们进一步了解DC如何控制吞噬的病原体和呈递抗原，以促进适应性免疫反应。