Functional analysis of genetic polymorphism associated with hematopoietic stem cell transplantation, and exploration for genome target therapy

造血干细胞移植相关基因多态性功能分析及基因组靶向治疗探索

• 批准号: 15K09513
• 负责人: Takami Akiyoshi
• 金额: $ 3.08万
• 依托单位: Aichi Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09513/
• 关键词: 造血幹細胞移植; 遺伝子多型; 免疫調整遺伝子多型; 一塩基多型

项目成果

Fibroblast Growth Factor-2 facilitates the growth and chemo-resistance of leukemia cells in the bone marrow by modulating osteoblast functions.

• DOI: 10.1038/srep30779
• 发表时间: 2016-08-02
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Sugimoto K;Miyata Y;Nakayama T;Saito S;Suzuki R;Hayakawa F;Nishiwaki S;Mizuno H;Takeshita K;Kato H;Ueda R;Takami A;Naoe T
• 通讯作者: Naoe T

Role of reduced-intensity conditioning allogeneic hematopoietic cell transplantation in older patients with de novo acute myeloid leukemia.

降低强度调理同种异体造血细胞移植在老年新发急性髓系白血病患者中的作用。

• DOI: 10.1007/s00277-016-2872-y
• 发表时间: 2017
• 期刊: Ann Hematol
• 影响因子: 3.5
• 作者: Yamasaki S;Hirakawa A;Aoki J;Uchida N;Fukuda T;Ogawa H;Ohashi K;Kondo T;Eto T;Kanamori H;Okumura H;Iwato K;Ichinohe T;Kanda J;Onizuka M;Kuwatsuka Y;Yanada M;Atsuta Y;Takami A;Yano S.
• 通讯作者: Yano S.

Effect of Granulocyte Colony-Stimulating Factor-Combined Conditioning in Cord Blood Transplantation for Myelodysplastic Syndrome and Secondary Acute Myeloid Leukemia: A Retrospective Study in Japan

• DOI: 10.1016/j.bbmt.2015.05.009
• 发表时间: 2015-09-01
• 期刊: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
• 影响因子: 4.3
• 作者: Konuma, Takaaki;Takahashi, Satoshi;Miyazaki, Yasushi
• 通讯作者: Miyazaki, Yasushi

Single-Nucleotide Polymorphism in the Pbk Gene Is Closely Associated with Myeloma Cell Proliferation

Pbk基因单核苷酸多态性与骨髓瘤细胞增殖密切相关

• 发表时间: 2017
• 作者: Hanamura I;Takami A
• 通讯作者: Takami A

Donor and Recipient Toll-Like Receptor 1 Variations Comparably Predict Transplant-Related Mortality after Unrelated Bone Marrow Transplantation

供体和受体 Toll 样受体 1 变异可预测无关骨髓移植后的移植相关死亡率

• 发表时间: 2016
• 作者: Uchino;K.;Mizuno;S.;Mizutani;M.;Horio;T.;Hanamura;I.;Espinoza;J. L.;Matsuo;K.;Onizuka;M.;Kashiwase;K.;Morishima;Y.;Fukuda;T.;Kodera;Y.;Doki;N.;Doki;N.;Miyamura;K.;Mori;T. and Takami;A.
• 通讯作者: A.