The mechanism how RasGRP4 promotes proliferation of synovial fibroblasts in rheumatoid arthritis

RasGRP4促进类风湿性关节炎滑膜成纤维细胞增殖的机制

• 批准号: 15K09514
• 负责人: Yasuda Shinsuke
• 金额: $ 2.91万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-10-21 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09514/
• 关键词: 関節リウマチ; 線維芽細胞様滑膜細胞; Ras; RasGRP4; farnesyltransferase; MAPキナーゼ; TNFα

项目成果

Role of apolipoprotein B100 and oxidized low-density lipoprotein in the monocyte tissue factor induction mediated by anti-b2 glycoprotein I antibodies.

载脂蛋白 B100 和氧化低密度脂蛋白在抗 b2 糖蛋白 I 抗体介导的单核细胞组织因子诱导中的作用。

• DOI: 10.1177/0961203316638165
• 发表时间: 2016
• 期刊: Lupus
• 影响因子: 2.6
• 作者: Otomo K;Amengual O;Fujieda Y;Nakagawa H;Kato M;Oku K;Horita T;Yasuda S;Matsumoto M;Nakayama KI;Hatakeyama S;Koike T;Atsumi T
• 通讯作者: Atsumi T

Tocilizumab reduced production of scleroderma-related autoantibodies and anti-cyclic citrullinated protein antibodies in two patients overlapping scleroderma and rheumatoid arthritis

托珠单抗减少了两名患有硬皮病和类风湿性关节炎的患者的硬皮病相关自身抗体和抗环瓜氨酸蛋白抗体的产生

• DOI: 10.1080/03009742.2017.1297482
• 发表时间: 2018
• 期刊: Scand J Rheumatol
• 影响因子: 2.1
• 作者: Kono M;Yasuda S;Kono M;Atsumi T
• 通讯作者: Atsumi T

Ribophorin II is involved in the tissue factor expression mediated by phosphatidylserine-dependent antiprothrombin antibody on monocytes

• DOI: 10.1093/rheumatology/kew005
• 发表时间: 2016-06-01
• 期刊: RHEUMATOLOGY
• 影响因子: 5.5
• 作者: Fujieda, Yuichiro;Amengual, Olga;Atsumi, Tatsuya
• 通讯作者: Atsumi, Tatsuya

Maintenance Treatment using Abatacept with Dose Reduction after Achievement of Low Disease Activity in Patients with Rheumatoid Arthritis (MATADOR) - A prospective, multicenter, single arm pilot clinical trial

类风湿关节炎患者达到低疾病活动度后使用阿巴西普维持治疗并减少剂量 (MATADOR) - 一项前瞻性、多中心、单臂试点临床试验

• DOI: 10.1080/14397595.2017.1286714
• 发表时间: 2017
• 期刊: Mod Rheumatol
• 影响因子: 2.2
• 作者: Yasuda S;Ohmura K;Kanazawa H;Kurita K;Kon Y;Ishii T;Fujieda Y;Jodo S;Tanimura K;Minami M;Izumiyama T;Matsumoto T;Amasaki Y;Suzuki Y;Kasahara H;Yamauchi N;Kato M;Kamishima T;Tsutsumi A;Takemori H;Koike T;Atsumi T
• 通讯作者: Atsumi T

AAA-ATPase p97 suppress apoptotic and autophagy-associated cell death in rheumatoid arthritis synovial fibroblasts

AAA-ATPase p97 抑制类风湿关节炎滑膜成纤维细胞凋亡和自噬相关细胞死亡

• 发表时间: 2016
• 期刊: Oncotarget
• 作者: Kato M;Ospelt C;Kolling C;Shimizu T;Kono M;Yasuda S;Michel BA;Gay RE;Gay S;Klein K;Atsumi T
• 通讯作者: Atsumi T