Molecular mechanism and clinical implications of Sigle-9 induced cell death of activated neutrophils.

Sigle-9 诱导活化中性粒细胞死亡的分子机制和临床意义。

• 批准号: 15K09661
• 负责人: Kano Gen
• 金额: $ 3万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09661/
• 关键词: Siglec; Cell death; neutrophil; eosinophil; Siglec-8; Siglec-9; ROS; mitochondria; p40phox; gp91phox; NOX2サブユニット; Siglec誘導性細胞死; 細胞内ROS産生機構; NOXサブユニット; Src family kinase; 細胞内局在; リン酸化; Proximity ligation assay

项目成果

Identification of reactive oxygen production site in Siglec-8 induced eosinophil death

Siglec-8 诱导嗜酸性粒细胞死亡中活性氧产生位点的鉴定

• DOI: 10.1016/j.jaci.2018.12.888
• 发表时间: 2019
• 期刊: Journal of Allergy and Clinical Immunology
• 影响因子: 14.2
• 作者: Toshihiro Tomii;Gen Kano
• 通讯作者: Gen Kano

Whole-exome sequencing identification of novel DNAH5 mutations in a young patient with primary ciliary dyskinesia.

• DOI: 10.3892/mmr.2016.5871
• 发表时间: 2016-12
• 期刊: Molecular medicine reports
• 影响因子: 3.4
• 作者: Kano G;Tsujii H;Takeuchi K;Nakatani K;Ikejiri M;Ogawa S;Kubo H;Nagao M;Fujisawa T
• 通讯作者: Fujisawa T