Functional analysis of small RNAs involved in tumorigenesis of a new molecular subtype of colorectal cancer, and investigation of their new molecular targets

结直肠癌新分子亚型肿瘤发生过程中小RNA的功能分析及其新分子靶点研究

• 批准号: 15K08962
• 负责人: TAKAHASHI MASANOBU
• 金额: $ 3.08万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08962/
• 关键词: miRNA; BRAF; 抗EGFR抗体; 大腸がん; BRAF変異; 大腸癌

项目成果

AACR Annual Meeting 2016

2016 年美国癌症协会年会

• 发表时间: 2016

Functional Complementation Assay for 47 MUTYH Variants in a MutY-Disrupted Escherichia coli Strain.

• DOI: 10.1002/humu.22794
• 发表时间: 2015-07
• 期刊: Human mutation
• 影响因子: 3.9
• 作者: Komine K;Shimodaira H;Takao M;Soeda H;Zhang X;Takahashi M;Ishioka C
• 通讯作者: Ishioka C

microRNA-193a-3p acts as a tumor suppressor in BRAF-mutated colorectal cancer

microRNA-193a-3p 在 BRAF 突变结直肠癌中充当肿瘤抑制因子

• 发表时间: 2016
• 作者: 1.Takahashi H;Takahashi M;Takahashi S;Shimodaira H;Ishioka;C
• 通讯作者: C

The G8 screening tool enhances prognostic value to ECOG performance status in elderly cancer patients: A retrospective, single institutional study.

• DOI: 10.1371/journal.pone.0179694
• 发表时间: 2017
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Takahashi M;Takahashi M;Komine K;Yamada H;Kasahara Y;Chikamatsu S;Okita A;Ito S;Ouchi K;Okada Y;Imai H;Saijo K;Shirota H;Takahashi S;Mori T;Shimodaira H;Ishioka C
• 通讯作者: Ishioka C

Efficacy and safety of denosumab versus zoledronic acid in delaying skeletal-related events in patients with gastrointestinal cancer, pancreas-biliary system cancer, and other rare cancers.

狄诺塞麦与唑来膦酸在延缓胃肠癌、胰胆管系统癌和其他罕见癌症患者骨骼相关事件方面的疗效和安全性。

• 发表时间: 2017
• 期刊: J Bone Oncol
• 影响因子: 3.4
• 作者: Imai H;Saijo K;Yamada H;Ohuchi K;Okada Y;Komine K;Takahashi M;Takahashi S;Takahashi M;Shimodaira H;Ishioka C.
• 通讯作者: Ishioka C.