Novel therapeutic strategy for atherosclerosis by regulating myeloid lineage cells in socially defeated mice

通过调节社交失败小鼠的骨髓谱系细胞治疗动脉粥样硬化的新策略

• 批准号: 15K09162
• 负责人: Yamada Hiroyuki
• 金额: $ 3万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09162/
• 关键词: うつ病; 動脈硬化; 好中球細胞外トラップ

项目成果

Maternal high-fat diet promotes palmitate-induced inflammasome activation of bone marrow derived macrophages from adult offspring: Possible mechanisms of increased susceptibility to insulin resistance.

母亲高脂肪饮食促进棕榈酸盐诱导成年后代骨髓来源巨噬细胞的炎症小体活化：胰岛素抵抗易感性增加的可能机制。

• 发表时间: 2017
• 作者: Wada N;Yamada H;Motoyama S;Yamamoto K;Terada K;Saburi M;Sugimoto T;Kikai M;Wakana N;Matoba S.
• 通讯作者: Matoba S.

Loss of MURC/Cavin-4 induces JNK and MMP-9 activity enhancement in vascular smooth muscle cells and exacerbates abdominal aortic aneurysm

• DOI: 10.1016/j.bbrc.2017.04.096
• 发表时间: 2017-06-03
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Miyagawa, Kotaro;Ogata, Takehiro;Matoba, Satoaki
• 通讯作者: Matoba, Satoaki

Transplantation of brown adipose tissue inhibits atherosclerosis in apoE deficient mice via activation of FGF-21/adiponectin axis.

棕色脂肪组织移植通过激活 FGF-21/脂联素轴抑制 apoE 缺陷小鼠的动脉粥样硬化。

• 发表时间: 2015
• 作者: Kikai M;Terada K;Yamamoto K;Motoyama S;Wada N;Wakana N;Yamada H.
• 通讯作者: Yamada H.

Short-Term Treatment with an Angiotensin II Receptor Blocker Prevents Necrotic Core Formation by Inhibiting Oxidative Stress-Mediated Apoptosis in Macrophages.

血管紧张素 II 受体阻滞剂的短期治疗可通过抑制巨噬细胞中氧化应激介导的细胞凋亡来防止坏死核心形成。

• DOI: 10.4172/2324-8602.1000252
• 发表时间: 2015
• 期刊: Int J Cardiovasc Res
• 作者: Kishida S;Yamada H;Wakana N;Kawahito H;Irie D;Kato T;Kikai M;Terada K;Yamamoto K;Wada N;Motoyama S;Takata H;Yokoi H;Tsubakimoto Y;Ogata T;Ueyama T;Satoaki M.
• 通讯作者: Satoaki M.

Repeated social defeat enhances neutrophil extracellular traps formation in vivo and in vitro: Potential implication in the exaggerated atherosclerosis in chronic social stress-exposed apoE-/- mice.

反复的社交失败在体内和体外增强了中性粒细胞胞外陷阱的形成：对慢性社交压力暴露的 apoE-/- 小鼠中过度动脉粥样硬化的潜在影响。

• 发表时间: 2017
• 作者: 36.Yamamoto K;Yamada H;Terada K;Motoyama S;Wada N;Saburi M;Kikai M;Wakana N;Matoba S.
• 通讯作者: Matoba S.