Studies on Clarification of Pathological Conditions of Osteoporosis in the Ora

口腔骨质疏松症病理学阐明的研究

• 批准号: 09470460
• 负责人: OHNO Kohsuke
• 金额: $ 6.72万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09470460/
• 关键词: osteoporosis; dental implant; estrogen; ovariectomized rat; tibia; jaw bones; 顎骨; エストロジェン; インプラント

The application of dental implant is significantly useful for the improvement masticatory dysfunction and impaired cosmetics due to missing teeth. The success implant therapy on the jaw bone and the consistent maintenance of this condition. It seems that the clinical course following the application of dental implant is also affected by the structure and components of the jaw bone in which the prosthesis is implanted. Recently several researchers have studied the individuals with osteoporosis and pointed out the decrease of trabecular bone in the jaw bone and the increase in the incidence of periodontal disease and missing tooth. These findings suggested the necessity of consider the pathological bone changes due to osteoporosis in the application of dental implant. In the present study, we conducted ovariectomy on female rats to prepare postmenopausal models and morphologically evaluated the effects of pathological bone changes on the bone reactions around the dental implants. In the individuals who showed the reduced quantity of jaw bone, their dental implants were not sufficiently supported probably because of the decrease in the tissues of circumferential bones, especially cancellous banes, in contact with the dental implant and the scantiness of circumferential bone trabeculae.In the present study, we used the proximal part of the tibia as a pathological model of osteoporosis. Considering the conditions of the present study, we should recognize the possible difference in pathological conditions between tibia and jaw bones.Therefore further studies on the pathological conditions of osteoporosis in the oral and maxillofacial region are necessary before the establishment of the guidelines for the application of dental implant in the individuals with osteoporosis.

牙种植体的应用对改善因缺牙引起的咀嚼功能障碍和美容效果有重要意义。成功的颌骨种植治疗和这种情况的持续维护。看来，牙科种植体应用后的临床过程也受到植入假体的颌骨的结构和成分的影响。近年来，一些研究者对骨质疏松症患者进行了研究，指出骨质疏松症患者颌骨中骨小梁减少，牙周病和牙齿缺失的发病率增加。提示在种植牙的应用中，应考虑骨质疏松引起的骨组织病理改变。在本研究中，我们对雌性大鼠进行卵巢切除，制备绝经后模型，并从形态学上评估病理性骨变化对牙种植体周围骨反应的影响。在显示颌骨数量减少的个体中，他们的牙种植体没有得到充分的支持，这可能是因为与牙种植体接触的周围骨组织，特别是松质骨巴内斯的减少和周围骨小梁的缺乏。考虑到目前的研究条件，我们应该认识到胫骨和颌骨的病理状况可能存在差异，因此在制定骨质疏松症个体应用牙种植体的指南之前，有必要对口腔颌面部骨质疏松症的病理状况进行进一步的研究。

项目成果

Yamazaki et al: "Bone reactions to titanium serew implants in ovariectomized animals"Oral Surg Oral Med Oral Dathol. 87. 411-418 (1999)

Yamazaki 等人：“卵巢切除动物对钛合金植入物的骨反应”Oral Surg Oral Med Oral Dathol。

徳川友希、他: "卵巣摘出ラットへのエストロゲンの補充投与とインプラント体周囲の骨反応"口科誌. 48. 121-133 (1999)

Yuki Tokukawa 等人：“卵巢切除大鼠的雌激素补充和种植体周围的骨反应”口腔医学杂志 48. 121-133 (1999)。

Yamazaki, M..et al.: "Bone reaction to titanium screw implants in ovarlectomized animals"Oral Surg Oral Med Oral Pathol. 87(4). 411-418 (1999)

Yamazaki, M..等人：“卵巢切除动物对钛螺钉植入物的骨反应”口腔外科口腔医学口腔病理。

Motohashi eta al: "Bone reaetions around hydroxylopotite-caatea implants in ovariectomized rats"Oral Surg Oral Med Oral Dathol. 87. 145-152 (1999)

Motohashi 等人：“卵巢切除大鼠中羟基磷灰石植入物周围的骨反应”Oral Surg Oral Med Oral Dathol。