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Functional phylogenetic analysis of developmental mechanisms of pigment cells

Functional phylogenetic analysis of developmental mechanisms of pigment cells
色素细胞发育机制的功能系统发育分析
批准号：
09440254
负责人：
YAMAMOTO Hiroaki
金额：
$5.76万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1997
资助国家：
日本
项目状态：
已结题
起止时间：
1997 至 1998
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09440254/
关键词：
Pigment cellTRP geneTyrosinase geneAscidiansVertebratesUrochordataPhylogenitic analysisGenomic analysis脊髄動物

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中文摘要
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英文摘要
The purpose of this project is as follows.1. Cloning of ascidian homologues for vertebrate genes involved in differentiation of pigment cells.2. Phylogenetic analysis of the genes and their expression patterns.3. Discussion of evolution of developmental systems of pigment cells.We obtained the following results.a. Putative ascidian MITF(microphthalmia-associated transcription factor) gene was cloned. We found that MITF-M is an essential isoform to allow differentiation of melanocyte from neural crest cells in vertebrates. Ascidian MITF homologue can not express the M-isoform.b. Ascidian MITF homologue can transactivate both ascidian tyrosinase (tyrs) and tyrosinase-related protein (TRP) genes but also vertebrate tyrs and TRP genes. On the other hand, only one of vertebrate MITF isoforms can transactivate the ascidian TRP gene.It is suggested that the MITF-M specific first exon and its regulatory sequence have obtained in the evolution of vertebrates.
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会议论文
Wada, H: "Neural tube is partially dorsalized by overexpression of HrPax-37 : The ascidian homologue of Pax-3 and Pax-7" Developmental Biology. 187. 240-252 (1997)
Wada, H：“神经管因 HrPax-37 的过度表达而部分背侧化：Pax-3 和 Pax-7 的海鞘同源物”发育生物学。
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通讯作者：
Yuasa, H.J.: "The structural organization of the ascidian, Halocynthia roretzi calmodulin genes : the vicissitude of introns during the evolution of calmodulin genes." Gene, accepted.(1999)
Yuasa, H.J.：“海鞘、Halocynthia roretzi 钙调蛋白基因的结构组织：钙调蛋白基因进化过程中内含子的变迁。”
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通讯作者：
Amae, S.et al.: "Identification of a novel isoform of microphthalmia-associated transcription factor that is enriched in pigment epithelium." Biochem.Biophys.Res.Comm.247. 710-715 (1998)
Amae, S.等人：“鉴定出一种新的小眼球相关转录因子亚型，该转录因子富含色素上皮。”
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通讯作者：
Sato, S.: "Ascidian tyrosinase gene:its unique structure and expression in the developing brain" Developmental Dynamics. 208. 363-374 (1997)
Sato, S.：“海鞘酪氨酸酶基因：其独特的结构和在发育中大脑中的表达”发育动力学。
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