The role of FoxM1 transcription factor in the development of hepatic inflammation, liver fibrosis, and hepatocellular carcinoma: the study using conditional transgenic mice

FoxM1转录因子在肝脏炎症、肝纤维化和肝细胞癌发展中的作用：使用条件转基因小鼠的研究

• 批准号: 26461001
• 负责人: YOSHIDA YUICHI
• 金额: $ 3.16万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2014
• 资助国家: 日本
• 起止时间: 2014-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461001/
• 关键词: FoxM1; 肝細胞癌; 肝細胞死; 炎症; トランスジェニックマウス; 肝癌; 肝内炎症; 肝線維化; HCC; NAFLD; 脂肪肝

项目成果

Hepatic aberrant glycosylation by N-acetylglucosaminyltransferase V accelerates HDL assembly.

• DOI: 10.1152/ajpgi.00231.2016
• 发表时间: 2016-11
• 期刊: American journal of physiology. Gastrointestinal and liver physiology
• 作者: Y. Kamada;Sachiho Kida;K. Hirano;Satoshi Yamaguchi;A. Suzuki;Chikako Hashimoto;A. Kimura;M. Sato;Hironobu Fujii;Tomoaki Sobajima;Akiko Yamamoto;Yusuke Ebisutani;S. Takamatsu;S. Shinzaki;Y. Yoshida;Makoto Yamada;H. Nagasaka;T. Takehara;E. Miyoshi

The impact of an inosine triphosphate pyrophosphatase genotype on bilirubin increase in chronic hepatitis C patients treated with simeprevir, pegylated interferon plus ribavirin.

肌苷三磷酸焦磷酸酶基因型对接受西美普韦、聚乙二醇干扰素加利巴韦林治疗的慢性丙型肝炎患者胆红素升高的影响。

• DOI: 10.1007/s00535-015-1105-9
• 发表时间: 2016
• 期刊: J Gastroenterol.
• 作者: Tahata Y;Hiramatsu N;Oze T;Morishita N;Harada N;Yamada R;Yakushijin T;Mita E;Hagiwara H;Yamada Y;Ito T;Hijioka T;Inada M;Katayama K;Tamura S;Yoshihara H;Inoue A;Imai Y;Irishio K;Kato M;Hikita H;Sakamori R;Miyagi T; Yoshida Y;Tatsum
• 通讯作者: Tatsum

急性肝不全病態においてGab1 は肝細胞運命の決定を担う

Gab1 在急性肝衰竭病理中决定肝细胞命运

• 发表时间: 2016
• 作者: 古田訓丸;吉田雄一;倉橋知英;小倉智志;柄川真弓;木曽真一;鎌田佳宏;竹原徹郎
• 通讯作者: 竹原徹郎

Loss of Gab1 adaptor protein in hepatocytes aggravates experimental liver fibrosis in mice

• DOI: 10.1152/ajpgi.00289.2014
• 发表时间: 2015-04-01
• 期刊: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
• 影响因子: 4.5
• 作者: Kizu, Takashi;Yoshida, Yuichi;Takehara, Tetsuo
• 通讯作者: Takehara, Tetsuo

Loss of Grb2-associated binder 1 results in enhanced hepatocyte necrosis and high mortality in mice with acute liver failure

Grb2 相关结合物 1 的缺失导致急性肝衰竭小鼠肝细胞坏死加剧和高死亡率

• 发表时间: 2014
• 作者: Kunimaro Furuta;Yuichi Yoshida;Takashi Kizu;Satoshi Ogura;Mayumi Egawa;Norihiro Chatani;Yoshihiro Kamada;Shinichi Kiso;Tetsuo Takehara
• 通讯作者: Tetsuo Takehara